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Principal Investigator: Dr. Sydney Moise
Contact Information: E-mail: nsm2@cornell.edu - Phone: 3-3029
Sponsor: American Kennel Club Canine Health Foundation
Grant Number: 080104
Title: Microarray Analysis for Cardiac Gene Expression in German
Shepherds with Sudden Death
Annual Direct Cost: $52,100
Project Period: 10/1/04 -9/30/06
Sudden death in dogs due to cardiac disease is common. Many of these dogs die because of abnormal beats of the heart. Such diseases are likely inherited in the dog. Breeds at risk for such a cardiac death include the Doberman pincher, Boxer, Great Dane, Irish Wolfhound, Afghan hound, Newfoundland and the German shepherd dog (GS). To discover the genetic mutations that cause the diseases in each of these dogs will take many years of work. Research to identify the means of marking abnormal genes will help us to find the mutations. Even though the mutations will be different, research in one breed will help other breeds as we can use the gained information as we search the canine genome for the fatal inherited mistake. GS have an inherited propensity for sudden death due to the occurrence of abnormal heart beats that develop primarily during sleep or with certain anesthetic agents. We have the needed pedigrees from GS for our research. In this proposal we put forth a comprehensive plan to used stored samples from GS that have died and their relatives so that we can identify potential abnormal genes and develop the markers for the most likely genes that could be involved in the disorder.
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