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Co-Principal Investigators: Dr. Barbara Baird, Dr. Hector Abruņa,
Dr. Christopher Ober, Dr. Judith Appleton, Dr. Theodore Clark
Contact Information: E-mail: jaa2@cornell.edu - Phone: 607-256-5648
E-mail: tgc3@cornell.edu - Phone: 607-253-4042
Sponsor: Cornell-Nanobiotechnology Center
Grant Number: N/A
Title: Biosensor Based on Electrochemical/Gravimetric Detection of Intrinsic Antibody Catalysis
Annual Direct Cost: $123,207
Project Period: 04/01/07-03/31/08
DESCRIPTION (provided by applicant): One or more novel devices will be developed for electrochemical/gravimetric detection of antibodies, in particular, antibodies specific for the avian influenza virus hemagglutinin protein H5. This approach takes advantage of the intrinsic catalytic activity of all antibodies, the antibody-catalyzed water oxidation pathway (ACWOP), that has been characterized in the literature. This activity will be detected on a specifically modified electrode or within a quartz crystal microbalance (QCM). These detection methods, within microscale devices, are expected to be more specific and more sensitive than current enzyme-linked-immuno-sorbant-assays (ELISAs).
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