Advancing the health and well-being of animals and people


Principal Investigator: John Schimenti

Department of Biomedical Sciences
Email: jcs92@cornell.edu; Phone: 607-253-3466
Sponsor: NIH-National Institute of General Medical Sciences (NIGMS)
Grant Number: 2R01GM045415-23
Title: Genetics of Meiosis and Recombination in Mice
Project Amount: $314,062
Project Period: 09/01/13-07/31/14

DESCRIPTION (Provided by Applicant): Meiosis is the critical process leading to formation of sperm and eggs. Errors that occur in meiosis, primarily those involving the proper behavior of chromosomes during this process, underlie birth defects, subfertility/sterility and failed pregnancies. This project studies the molecular identity of genetic quality control mechanisms  called "checkpoints" that normally guard against production of defective eggs and sperm, and will delineate how these mechanisms function. We will exploit this knowledge to identify inhibitors of these checkpoints that can be used to protect the eggs of  female cancer patients from chemotherapies that would otherwise destroy the eggs.