Mouse spermatocyte at diplotene of meiosis I Metaphase mouse oocyte. Human oocyte from a trisomy 21 individual.  

Advancing the health and well-being of animals and people

Biochemistry & Cell Biology

Research at the College of Veterinary Medicine meets the clinical and research demands of human and animal health. Consistently ranked among the top veterinary colleges in the country, the College leads in scientific discovery. Faculty expertise focuses on the interface between scientific research and clinical practice as well as a commitment to animal and human health.

Faculty Index
Area of Interest
Basic genetics, cell biology, and molecular biology of the ciliated protozoan Tetrahymena thermophila, application of techniques developed in this versatile organism to other biologically important protozoa
Immunology; Mechanisms of immune evasion; Tetrahymena as a high-level expression system for vaccine antigens; Evolution of antigen presentation
Role of the DNA mismatch repair (MMR) family in mammalian meiosis and recombination; RNA binding Argonauts in germline and other mammalian tissue stem cells; Genetics and development; Gamete biology, fertilization & reproductive tract
Examination of how the chemical reactions of biology are organized in time and space, and how this organization is harnessed by cells to generate distinct outcomes; Molecular basis of cell growth and differentiation; Biochemical and genetic studies of Rab GTPases; Role of Yip family members in membrane traffic
Equine immune system with specific interest in immunodeficiencies and developmental immunity of the foal; immunomodulatory therapies and response to vaccines; comparative animal model for human disease research
Ion channels and their role in inflammatory response and pain sensation
Immunology; Innate immunity: Toll-like receptors, signaling, dendritic cells, and controlling microbial infection
Developmental biology; axon guidance and target formation during the development of the mouse olfactory system, using genetic, in vitro, and genomic approaches
Cell biology and enzymology of protein palmitoylation
Identification and characterization of stem cells in the adult small intestinal epithelium, focusing on cell surface markers and gene expression by microarray analysis

Carolyn Sevier
Carolyn Sevier

Molecular mechanisms regulating cellular oxidative folding and stress pathways using a combination of molecular, genetic, and biochemical techniques
Signal transduction and exocytosis in the pancreatic beta-cell
Sperm motility regulation and transport into the female reproductive tract
Micro and nano-biotechnology; biomaterials & drug delivery; Reproductive Physiology; Cell biology of male germ cells; preservation of genetic diversity; comparative biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft membrane sub-domains in sperm; applications of technologies using reproductive stem cells for wildlife conservation
Virology; Endocytosis of influenza virus, structure-function studies on influenza HA, entry of coronaviruses and rhabdoviruses into host cell; feline infectious peritonitis