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Advancing the health and well-being of animals and people


Infection & Immunity

Research at the College of Veterinary Medicine meets the clinical and research demands of human and animal health. Consistently ranked among the top veterinary colleges in the country, the College leads in scientific discovery. Faculty expertise focuses on the interface between scientific research and clinical practice as well as a commitment to animal and human health.

Faculty Index

Faculty
Area of Interest
Limitations of the canine and equine respiratory system in health and disease; Control of breathing in cursorial mammals; Pulmonary immunology in equids; Respiratory system biology in equids
Environmental cues of the intestinal tract that induce virulence gene expression in Salmonella; Defining the genetic pathways by which environmental signals are communicated in Salmonella to cause changes in virulence gene expression; genetic and genomic approaches to characterize this regulon

 

Biological interactions that take place between a mother and fetus during pregnancy genes & development; Equine medicine with emphasis on immunology, genetics, and reproduction
Parasitic diseases; Mucosal immunity in the intestinal tract, specifically intestinal immunity expressed against parasitic nematodes
Immune cell activation and signaling in development, response to infection and respiratory inflammation
Joel D. Baines
Joel Baines
Molecular biology and biochemistry of herpesvirus assembly, envelopment, and cellular exit; Herpesvirus neurovirulence; cell biology of herpesvirus induced changes in cultured cells
Parasitic diseases; internal medicine; small animal medicine
Dairy production medicine; Bacteriology; prevention and treatment of infection; Antibiotic therapies in livestock
Soil transmitted parasites, parasites of wildlife, visceral larva migrans, host response to soil transmitted pathogens, detection of soil transmitted parasites
Infectious and non-infectious diseases of fish, pathogenesis of important bacterial pathogens of cultured and wild fish, evaluation of new therapeutic compounds for use in cultured food fish
Molecular pathogenesis of the infectious bronchitis virus; Ecology and conservation of disease in birds and wildlife
Host intracellular signaling pathways during Toxoplasma infection; role of neutrophils during toxoplasmosis
Molecular basis of antigen-induced immune tolerance, the modulation of the innate immune system response in immunity against cancer, the role of extracellular adenosine in the regulation of central nervous system barrier permeability and gut epithelial barrier permeability
Oncogenesis in wild populations, primarily in fish and marine turtles; Eukaryotic gene regulation; oncogenic transformation; viral replication and pathogenesis; toxicology, with special emphasis on viral hemorrhagic septicemia (VHSV)

DCassidy-Hanley
Donna Cassidy-Hanley

Basic genetics, cell biology, and molecular biology of the ciliated protozoan Tetrahymena thermophila, application of techniques developed in this versatile organism to other biologically important protozoa
Molecular biology of infectious disease; DNA and recombinant subunit vaccine development; molecular basis of bacterial pathogenesis; immunopathology of infectious disease; molecular diagnosis of infectious diseases; host defense mechanisms; comparative genomics and proteomics
Immunology; Mechanisms of immune evasion; Tetrahymena as a high-level expression system for vaccine antigens; Evolution of antigen presentation
Examination of how the chemical reactions of biology are organized in time and space, and how this organization is harnessed by cells to generate distinct outcomes; Molecular basis of cell growth and differentiation; Biochemical and genetic studies of Rab GTPases; Role of Yip family members in membrane traffic
Host intracellular signaling pathways during Toxoplasma infection; role of neutrophils during toxoplasmosis
Developmental immunotoxicology; capacity of drugs, environmental chemicals, and dietary factors to produce persistent immunotoxicologic responses in juvenile and adult offspring following early life exposure; immune susceptibility to toxicants
Equine and bovine internal medicine and critical care; Equine motor neuron disease, equine lyme disease, equine protozoal myelitis and any advances in internal medicine and critical care for large animals
Viral diseases of cattle; Bovine viral diarrhea virus; Viral diseases of dogs; Canine influenza virus; Viral diseases of domestic animals that impact endangered wildlife; Herd health program; Biosecurity; effective use of veterinary biologicals
Molecular mechanisms of host-parasite interactions and their relationship to susceptibility or resistance against enteric bacterial diseases, particularly within the framework of animal models of colitis
Equine immune system with specific interest in immunodeficiencies and developmental immunity of the foal; immunomodulatory therapies and response to vaccines; comparative animal model for human disease research; Mechanisms of regulation of B cell differentiation using equine bone marrow- and fetal liver-derived hematopoietic stem cells
Infectious disease and host immune response
West Nile Virus; Molecular Diagnostics; Virology; Surveillance Testing

Jagne DVM
Jarra Jagne

Agricultural Development, Community-based Approaches, International Development (Livestock Diseases And Livestock Production), Public Health, Sustainable Agriculture; poultry testing, consultation and extension services for commercial and backyard poultry producers
Basic metabolism in ruminants and genetics; epidemiological and mathematical modeling, genetic analysis and economic methods; food safety; zoonotic infectious diseases; optimizing dairy herd health and management decisions
Infectious Diseases, Epidemiology, and Reintroduction Medicine affecting Wildlife Health and Conservation
Opthalmology; discovering, identifying, and characterizing ocular infectious diseases
Immunology; Innate immunity: Toll-like receptors, signaling, dendritic cells, and controlling microbial infection
Cell and microbe interactions; facultative intracellular Gram-positive bacterium Listeria monocytogenes
Enterobacteriaceae and the microbial ecology of the intestinal tract; virulence mechanisms and pathogenesis of enteric bacterial infections, immunity to Salmonella infections; Salmonella epidemiology and control programs; antimicrobial resistance in bacteria; development of new diagnostic assays and media for use in veterinary clinical microbiology; development of biosensors for the rapid detection of microorganisms
Diseases of multiple species, defining epidemiology and risk factors for diseases;
epidemiology of infectious diseases; quantitative and analytical epidemiology; veterinary public health and food safety; production medicine
Epidemiological, statistical and mathematical methods to animal disease involving well managed dairy herds; udder health in well-managed dairy herds based on epidemiology and pathobiology
Production animal agriculture and public health; infectous calf diseases; herd health and performance
Retroviruses; calciviruses; virus structure; virus assembly; virus-host interactions; oncolytic viruses; virology
Virology; Adeno-associated viruses; animal viruses; viral protein structure; mechanisms of binding to different receptors; how differences in viral structural proteins can control their host ranges; the processes of cell infection, and how antibody binding can neutralize the virus in some cases but not others; biomaterials & drug delivery
Equine animal medicine; virology; herpesvirus; gastrointestinal diseases

Rudd
Brian Rudd

Infectious diseases, vaccinations, T cell production, defects in neonatal T cells, immunology
The biology of intracellular infection with emphasis on mycobacteria
Identifying strategies for reducing unnecessary pet euthanasias and enhancing the welfare of companion animals in society using epidemiologic approaches
Epidemiological, statistical and mathematical methods to animal disease involving well managed dairy herds; udder health in well-managed dairy herds based on epidemiology and pathobiology
Biology of intracellular infection by the Chlamydia bacterium
Internal Medicine and gastroenterology; role of Helicobacter in gastrointestinal disease; Inflammatory Bowel Disease
Molecular evolution and comparative genomics of infectious disease organisms
Duck disease control, good husbandry practices, nutrition, duck production, improvement of diagnostic techniques and the development of new or improved duck biologics.
Gastrointestinal and liver diseases of domestic animals, viral hepatitis, mechanisms of hepatic injury and hepatocarcinogenesis
Disease prevention, surveillance, and control programs; Ruminant and Equine Medicine extension field service
Antibody mediated immune mechanisms in infectious disease and vaccination; allergic diseases; neonatal tolerance and allergy predisposition; strategies to develop allergy treatments
dairy cattle epidemiology; preharvest food safety; Salmonellosis in cattle; infectious disease
Epidemiological, statistical and mathematical methods to animal disease involving well managed dairy herds
Herd Health Management; product evaluation (e.g. milking equipment, diagnostic instruments, therapeutic compounds, teat dips, and bedding additives); epidemiological modeling; molecular strain typing
Virology; Endocytosis of influenza virus; structure-function studies on influenza HA, entry of coronaviruses and rhabdoviruses into host cell; feline infectious peritonitis
Herd Health Management; product evaluation (milking equipment, diagnostic instruments, therapeutic compounds, teat dips, and bedding additives); epidemiological modeling; molecular strain typing