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Advancing the health and well-being of animals and people


Pharmacology & Toxicology

Research at the College of Veterinary Medicine meets the clinical and research demands of human and animal health. Consistently ranked among the top veterinary colleges in the country, the College leads in scientific discovery. Faculty expertise focuses on the interface between scientific research and clinical practice as well as a commitment to animal and human health.

Faculty Index Faculty A-C Faculty D-L Faculty M-R Faculty S-Z

Faculty
Area of Interest
Ion channel receptor and ligand interactions; NMR and molecular dynamics; molecular neurobiology and biophysics; neurotransmitter receptors and signal transduction
Immune cell activation and signaling in development, response to infection and respiratory inflammation
Analytical and heavy metals Toxicology in livestock and companion animals
Infectious and non-infectious diseases of fish, pathogenesis of important bacterial pathogens of cultured and wild fish, evaluation of new therapeutic compounds for use in cultured food fish
Understanding the molecular mechanisms by which signals are transmitted from cell surface receptors to biological effectors; identification of new signaling molecules that influence the growth and differentiation of mammalian cells
Examination of how the chemical reactions of biology are organized in time and space, and how this organization is harnessed by cells to generate distinct outcomes; Molecular basis of cell growth and differentiation; Biochemical and genetic studies of Rab GTPases; Role of Yip family members in membrane traffic
Identification and characterization of genes that are mutated in breast tumors; Reproductive biology; investigation of the role that novel, highly-abundant, and egg-restricted molecules play in reprogramming process; Epigenetic regulation of preimplantation development and embryonic fate decisions
Central nervous system regulation; investigations employ the interdisciplinary approach of functional genomics; Basic mechanisms of function, control and signaling in the cardiovascular system in health and disease; understanding the molecular mechanisms underlying hypertension and heart failure and the pregnancy-induced cardiovascular syndrome pre-eclampsia
Developmental immunotoxicology; capacity of drugs, environmental chemicals, and dietary factors to produce persistent immunotoxicologic responses in juvenile and adult offspring following early life exposure; immune susceptibility to toxicants
Calcium as a second messenger in non-excitable cells, protein kinase C, exocytosis proteins, ion channels in mast cells
Hormonal regulation of the differentiation and function of ovarian follicles; effects of endocrine disrupting chemicals on the bovine species
Infectious disease and host immune response

ToshiToshimitsu Kawate

Ion channels and their role in inflammatory response and pain sensation
Infectious Diseases, epidemiology, and reintroduction medicine affecting Wildlife Health and Conservation
Biomedical imaging; cellular excitation and relaxation; sarcoplasmic reticular calcium release channels; molecular processes underlying excitation-contraction coupling; sarcolemnal ion channels; molecular processes underlying cardiac stem cell and smooth muscle cell development and function
Transcriptional and cellular control of tissue morphogenesis; molecular and cellular events that direct the formation of tissues and organs during vertebrate embryogenesis; cell signaling; cellular behaviors and cell shape during development

Biomedical imaging; cellular excitation and relaxation; sarcoplasmic reticular calcium release channels; molecular processes underlying excitation-contraction coupling; sarcolemnal ion channels; molecular processes underlying cardiac stem cell and smooth muscle cell development and function
Cell biology and enzymology of protein palmitoylation
Molecular mechanisms of endocrine disruption, environmental toxicology, toxicogenomics, seasonal breeders and circadian rhythmicity
 
Cellular physiology; receptor pharmacology; membrane biophysics
Ion channel receptor and ligand interactions; NMR and molecular dynamics; molecular neurobiology and biophysics; neurotransmitter receptors and signal transduction
Regulation of pituitary-specific gene expression by gonadotropin-releasing hormone; Regulation of placental trophoblast cell function by combinatorial signaling; biomaterials & drug delivery

Carolyn Sevier
Carolyn Sevier

Molecular mechanisms regulating cellular oxidative folding and stress pathways using a combination of molecular, genetic, and biochemical techniques
Signal transduction and exocytosis in the pancreatic beta-cell
Deciphering the basic regulatory principles in signal transduction networks on a molecular level using a combination of X-ray crystallography, biophysical and cellular approaches; bacterial signaling controlling biofilm formation and pathogenicity; endocytosis in eukaryotes
Modulation of receptor properties by neurotransmitters and drugs
Genome maintenance mechanisms, cellular responses to genotoxins; mouse cancer models, DNA damage signaling, genomic instability; lung stem cells
Virology; Endocytosis of influenza virus; structure-function studies on influenza HA, entry of coronaviruses and rhabdoviruses into host cell; feline infectious peritonitis
Cell cycle regulation; cell differentiation; myeloblastic hematological tumor cell line, HL-60; Cancer chemoprevention; biomaterials & drug delivery; oncogenes; genetics