Immunology Over Lunch - David Russell, Sabine Ehrt, & Tiago Alfredo Rodrigues Beites

Tuesday, March 2, 2021 - 1:00pm

Immunology Over Lunch events are designed to foster scientific exchanges and connections in a fun, informal environment. Join us for short lunchtime lectures and questions-and-answer sessions with guest lecturers. This Immunology Over Lunch event features Sabine Ehrt, David Russell, and Tiago Alfredo Rodrigues Beites from 1-2pm on March 2.

Introduction to Mycobacterium tuberculosis 
Sabine Ehrt
Professor of Microbiology and Immunology, Division of Microbiology and Immunology, Weill Cornell Medical College

The significance of in vivo heterogeneity of host & pathogen in tuberculosis
David Russell
The William Kaplan Professor of Infection Biology, Department of Microbiology and Immunology, College of Veterinary Medicine

Mycobacterium tuberculosis remains a major impact on human health globally.  Our ability to manage this disease is compromised by the absence of a vaccine and the protracted nature of chemotherapy.  This talk will discuss how the interplay between the bacterium and its host cells in vivo impact disease progression, vaccine development and drug susceptibility.  We use a combination of fluorescent Mtb fitness reporter strains, genetic manipulation of host and microbe, and multi-modal RNA-seq analysis to probe this complex biology and to inform novel therapeutics.    

Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro & during infection
Tiago Alfredo Rodrigues Beites
Post-Docrotal Researcher; Instructor in Microbiology and Immunology, Microbiology and Immunology , Weill Cornell Medical College

Mycobacterium tuberculosis is dependent on host lipids as carbon sources. Although relevant for infection, fatty acid β-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitubercular drugs targeting this metabolic pathway. In this work, we identified a previously unrecognized enzyme complex composed of an electron transfer flavoprotein and a cognate dehydrogenase that is essential for fatty acid β-oxidation in M. tuberculosis.