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New Treatment for Osteoarthritis of the Canine Elbow

Canine

Arthritis is a common, painful condition in many dogs. There aren't many effective pain relief methods that are safe for long term use. We’ve developed a new, synthetic, joint lubricant (called Lubrisynth TM), which, when injected into the joint with arthritis, should aid in reducing pain and improving mobility without needing drugs such as NSAIDs (non-steroidal anti-inflammatory drugs).

Eligibility: Dogs with a history of elbow dysplasia who've had arthroscopy who now have arthritis in both elbows with no bone chips present in the joints and no other orthopedic (bone/joint) disease

Compensation: This is a fully funded study, which means all costs related to the study are paid for by the sponsor. Additionally owners will be given a $500 honorarium at study completion to help defray travel costs for the frequent rechecks.

Owner Responsibilities: The commitment asked to participate in the study is as follows:

  1. Your dog will be evaluated for baseline joint and gait function using a force plate. This evaluation involves your dog walking and trotting over a length of pad ~15 feet long that measures how much weight your dog is placing on each paw.
  2. Your dog will then be sedated and the joints will be visualized with a CT scan to confirm arthritis in both joints, and to ensure no bone fragments are present (if bone fragments are found, your dog will not be eligible for the study). The study will pay 100% of the costs even if your dog is excluded at this point.
  3. Immediately following the CT your dog will have a needle inserted into both joints (at separate times) and joint fluid will be drawn out. One joint will then be injected with the study product (LubrisynthTM) and the other will be injected with the control liquid that is used with the LubrisynthTM to make it injectable. This does not contain any LubrisynthTM but is being done to make sure the injection itself or the fluid in the injection doesn’t have an effect.  Because the study is blinded you won't know which joint is getting which treatment.
  4. You will be required to bring your dog for clinical evaluation and gait analysis at study start and then (+/-1), 2, 4, 8, 12 and 26 weeks after the injections.

Contact/Schedule an Appointment: Please call the clinical trials coordinator at 607.253.3060 or email vet-research@cornell.edu.

Principal Investigators: Ursula Krotscheck, DVM, DACVS, Kei Hayashi, DVM, PhD, DACVS

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