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Daniel Paushter , DVM, Ph.D.

Faculty Mentor: Dr. Fenghua Hu 
Current Position: Staff Scientist, Fred Hutchinson Cancer Center (Seattle, WA)


Education 
DVM, Cornell University 
Ph.D., Cornell University 
B.S., University of Illinois at Urbana-Champaign


Publications:

  1. Santos MN, Paushter DH, Zhang T, Wu X, Feng T, Lou J, Du H, Becker SM, Fragoza R, Yu H, Hu F. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. J Biol Chem. 2022 Sep;298(9):102348. doi: 10.1016/j.jbc.2022.102348.
  2. Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Enriquez LCM, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F. A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain. 2020 Jul 1;143(7):2255-2271. doi: 10.1093/brain/awaa154.
  3. Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Enriquez LCM, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F. A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain. 2020 Jul 1;143(7):2255-2271. doi: 10.1093/brain/awaa154.
  4. Zhou X, Paushter DH, Pagan MD, Kim D, Nunez Santos M, Lieberman RL, Ovesrkleeft HS, Sun Y, Smolka MB, Hu F. Progranulin deficiency leads to reduced glucocerebrosidase activity. PLoS One. 2019 Jul 10;14(7):e0212382. doi: 10.1371/journal.pone.0212382.
  5. Paushter DH. The roles of progranulin and TMEM106B in lysosomal physiology and neurodegenerative disease. [dissertation]. [Ann Arbor, Michigan]: ProQuest Information and Learning; 2018. 210 p.
  6. Zhou X, Sullivan PM, Paushter DH, Hu F. The Interaction Between Progranulin with Sortilin and the Lysosome. Methods Mol Biol. 2018;1806:269-288. doi: 10.1007/978-1-4939-8559-3_18.
  7. Paushter DH, Du H, Feng T, Hu F. The lysosomal function of progranulin, a guardian against neurodegeneration. Acta Neuropathol. 2018 Jul;136(1):1-17. doi: 10.1007/s00401-018-1861-8.
  8. Zhou X*, Paushter DH*, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017 Aug 23;12(1):62. doi: 10.1186/s13024-017-0205-9.
    *Equal contributors
  9. Zhou X, Paushter DH, Feng T, Pardon CM, Mendoza CS, Hu F. Regulation of cathepsin D activity by the FTLD protein progranulin. Acta Neuropathol. 2017 Jul;134(1):151-153. doi: 10.1007/s00401-017-1719-5.
  10. Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Acta Neuropathol Commun. 2016 May 18;4(1):51. doi: 10.1186/s40478-016-0324-5. PMID: 27193190; PMCID: PMC4870812
  11. Wang Y, Danielson KK, Ropski A, Harvat T, Barbaro B, Paushter D, Qi M, Oberholzer J. Systematic analysis of donor and isolation factor's impact on human islet yield and size distribution. Cell Transplant. 2013;22(12):2323-33. doi: 10.3727/096368912X662417.
  12. Paushter DH, Qi M, Danielson KK, Harvat TA, Kinzer K, Barbaro B, Patel S, Hassan SZ, Oberholzer J, Wang Y. Histidine-tryptophan-ketoglutarate and University of Wisconsin solution demonstrate equal effectiveness in the preservation of human pancreata intended for islet isolation: a large-scale, single-center experience. Cell Transplant. 2013;22(7):1113-21. doi: 10.3727/096368912X657332.
  13. Wang Y, Mendoza-Elias JE, Qi M, Harvat TA, Ahn SJ, Lee D, Gutierrez D, Jeon H, Paushter D, Oberholzer J. Implication of mitochondrial cytoprotection in human islet isolation and transplantation. Biochem Res Int. 2012;2012:395974. doi: 10.1155/2012/395974.
  14. Qi M, Lacik I, Kolláriková G, Strand BL, Formo K, Wang Y, Marchese E, Mendoza-Elias JE, Kinzer KP, Gatti F, Paushter D, Patel S, Oberholzer J. A recommended laparoscopic procedure for implantation of microcapsules in the peritoneal cavity of non-human primates. J Surg Res. 2011 Jun 1;168(1):e117-23. doi: 10.1016/j.jss.2011.01.040.
  15. Wang Y, Paushter D, Wang S, Barbaro B, Harvat T, Danielson KK, Kinzer K, Zhang L, Qi M, Oberholzer J. Highly purified versus filtered crude collagenase: comparable human islet isolation outcomes. Cell Transplant. 2011;20(11-12):1817-25. doi: 10.3727/096368911X564994.