Skip to main content

Cassandra M B Guarino

Assistant Professor of Practice

Department of Population Medicine and Diagnostic Sciences

Bacteriology

Cornell University College of Veterinary Medicine
Ithaca, NY 14853

Office: 607-253-4343
Email: cg82@cornell.edu

Profile

Research/Clinical Interests

Dr. Guarino’s research interests include various aspect of clinical microbiology, from improving organism identification methodologies, to understanding antimicrobial resistance trends. Dr. Guarino also has a keen interest in the development of novel serologic assays for the diagnosis of infection with viral and bacterial pathogens in companion and production animals.

Education

  • Ph.D. Comparative Biomedical Sciences: minors in Biomedical Engineering and Molecular and Integrative Physiology, Cornell University (2013)
  • B.S. Animal Science/Agricultural Technology, Cornell University (2004)

Biography/Professional Experience

  • 2023-present: Assistant Professor of Practice, Bacteriology Laboratory Director, Animal Health Diagnostic Center, Cornell University
  • 2016-2023: Extension Associate for Serology/Immunology, Animal Health Diagnostic Center, Cornell University
  • 2013-2015: Postdoctoral Associate,, Biomedical Engineering, Cornell University
  • 2013: Postdoctoral Associate, Chemical and Biomolecular Engineering, Cornell University
  • 2004-2006: Medical Technologist, Animal Health Diagnostic Center, Cornell University

Awards and Honors

  • 2010-2012 NSF GK-12 fellowship, CLIMB, Cornell University
  • 2002-2004 Morrison Award, Cornell University

Professional/Academic Affiliations

  • American Society of Microbiology (ASM)
  • United States Animal Health Association (USAHA)
  • American Association of Immunologists (AAI)
  • American Association of Veterinary Laboratory Diagnosticians (AAVLD)

Publications

Selected Publications

  1. Pearson EK, Guarino C, Cercone M, Divers T, Lambert J, Garcia-Lopez J, Johnson AL, Engiles J, Brown K, Pinn-Woodcock T. (2024) Association of Borrelia burgdorferi with nuchal bursitis and elevated OspA-specific serum antibodies in horses. JAVMA. 262(11):1476. https://doi-org.proxy.library.cornell.edu/10.2460/javma.24.05.0312
  2. Williams C, Taetzsch S, Cutter L, Sunavala Z, Pieracci E, Negron M, Tiller R, Miller N, Austin C, Ernst M, Slager S, Hsio SH, Hung CC, Maddox CM, Lanka S, Pinn-Woodcock T, Guarino C, Franklin-Guild R, Arenas A, Gonazales DG, Pieracci E. (2024) Human exposures to Brucella canis from a pregnant dog imported into the United States during an international flight: Public health risks, diagnostic challenges, and future considerations. https://doi.org/10.1111/zph.13121
  3. Cobo-Angel C, Mosaddegh A, Aprea M, Guarino C, Cummings K, Cazer C. (2023) Trends of feline Escherichia cli minimum inhibitory concentration over 14 years illustrate the need for judicious antimicrobial use in cats. AJVR. 84(12). https://doi.org/10.2460/ajvr.23.09.0216.
  4. Pinn-Woodcock T, Frye E, Guarino C, Franklin-Guild R, Newman AP, Bennett J, Goodrich E. (2023) A one-health review on brucellosis in the United States. JAVMA. 261(4):451. https://doi.org/10.2460/javma.23.01.0033.
  5. Guarino C, Franklin-Guild R, Goodrich E, Conklin R, Frye E, Pinn-Woodcock T. (2023) Antibody response over time correlated with treatment outcome in 30 dogs naturally infected with Brucella canis (2017-2022). 84(4). https://doi.org/10.2460/ajvr.23.01.0014
  6. Guarino C, Larson E, Babasyan S, Rollins A, Joshi L, Laverack M, Parrilla L, Plocharczyk E, Diel DG, Wagner B. (2022) Development of a quantitative COVID-19 Multiplex Assay and its use for serological surveillance in a low SARS-CoV-2 incidence community. Plos ONE. 12(1):e0262868. https://doi.org/10.1371/journal.pone.0262868.
  7. Guarino C, Pinn-Woodcock T, Levine D, Miller J, Johnson A. (2021) Nuchal bursitis associated with Borrelia burgdorferi infection in a horse. Front Vet Sci. 8:743067. https://doi.org/10.3389/fvets.2021.743067
  8. Palmer MV, Martins M, Falkenberg S, Buckley A, Caserta LC, Mitchell PK, Cassmann ED, Rollins A, Zylich NC, Renshaw RW, Guarino C, Wagner B, Lager K, Diel DG. (2021) Susceptibility of White-Tailed Deer (Odocoileus Virginianus) to SARS-CoV-2. bioRxiv 2021.01.13.426628. https://doi.org/10.1101/2021.01.13.426628.
  9. Goodrich E L, McLean A, & Guarino C (2020) A Pilot Serosurvey for Selected Pathogens in Feral Donkeys (Equus asinus). Animals (Basel). 10(10):1796. https://doi.org/10.3390/ani10101796
  10. Guarino C, Asbie S, Rohde J, Glaser A, Wagner B. (2017) Vaccination of horses with Lyme vaccines for dogs induces short-lasting antibody responses. Vaccine. 35(33):4140. https://doi.org/10.1016/j.vaccine.2017.06.052
  11. Watkins HC, Pagan CL, Childs HR, Posada S, Chau A, Rios J, Guarino C, DeLisa MP, Whittaker GR and Putnam D. (2017) A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles. Vaccine. 35(40):5373. https://doi.org/10.1016/j.vaccine.2017.08.013
  12. Rappazzo CG and Watkins HC, Guarino C, Chau A, Lopez JL, DeLisa MP, Leifer CA, Whittaker GR, Putnam D. (2016) Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/C mice. Vaccine. 34(10):1252. https://doi.org/10.1016/j.vaccine.2016.01.028
  13. Ollis A, Chai Y, Natarajan A, Perregaux E, Jaroentomeechai T, Guarino C, Smith J, Zhang S, DeLisa MP. (2015) Substitute sweetners: diverse bacterial oligosaccharyltransferases with unique N-glycosylation site preferences. Scientific Reports. 5:15237 https://doi.org/10.1038/srep15237
  14. Mansell TJ, Guarino C, DeLisa MP. (2013) Engineered genetic selection links in vivo protein folding and stability with asparagine-linked glycosylation. Biotechnol J. 8(12):1445. https://doi.org/10.1002/biot.201300026
  15. Guarino C, DeLisa MP. (2012) A prokaryote-based cell-free translation system that efficiently synthesizes glycoproteins. Glycobiology 22(5):596. https://doi.org/10.1093/glycob/cwr151
  16. Fisher AC, Haitjema CH, Guarino C, Celik E, Endicott C, Reading CA, Merrit JH, Ptak AC, Zhang S, DeLisa MP. (2011) Production of secretory and extracellular N-linked glycoproteins in Escherichia coli. AEM 77:871. https://doi.org/10.1128/aem.01901-10
  17. Celik E, Fisher AC, Guarino C, Mansell TJ, DeLisa MP. (2010) A filamentous phage display system for N-linked glycoproteins. Prot Sci. 19:2006. https://doi.org/10.1002/pro.472