A Single Amino Acid Substitution Humanizes Mouse CD28, Increasing Effector and Stem-like T Cell Activation
Student Name:
Alexander Brady
Student Concentration:
Immunology and Infectious Disease
Principal Investigator:
Mandy McGeachy
Degree Conferral Date:
August 2025
Committee Member 1:
Deborah Fowell
Committee Member 2:
Brian Rudd
Committee Member 3:
Gary Whittaker
Publications:
Brady AE, Revu S, Wu D, Fisk H, Kone K, Lydecker A, Purser EJ, Smith N, Hilt ZT, Woodyear S, Caddy S, Gingras S, Rudd B, McGeachy MM. Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors. bioRxiv [Preprint]. 2025 Mar 13:2025.03.10.642460. doi: 10.1101/2025.03.10.642460. PMID: 40161835; PMCID: PMC11952375.