Magnetic resonance imaging is the reference standard for evaluation of intracranial neoplasia in small animals; however, its clinical use may be limited by availability, prolonged acquisition times, motion sensitivity, anesthesia considerations, and contraindications related to implants or patient stability. Photon-counting detector computed tomography is an emerging computed tomographic technology that directly converts X-ray photons into electrical impulses, yielding improved spatial resolution and enhanced iodine contrast compared with conventional energy-integrating computed tomographic systems. In human neuroimaging, dynamic contrast-enhanced photon-counting computed tomography has demonstrated the ability to identify intracranial tumors that are equivocal or occult on magnetic resonance imaging, particularly in technically challenging cases. Despite these promising findings, the diagnostic performance and reproducibility of photon counting computed tomography for small-animal brain neoplasia remain untested. Magnetic resonance imaging is used as the reference standard in this study because histopathologic confirmation is not routinely available in client-owned patients.