We seek to purchase upgrades for a Keyence BZ-X810 all-in-one fluorescence microscope maintained by the Department of Biomedical and Translational Sciences. This microscope has many capabilities and is widely used by members of both the previous Department of Molecular Medicine and Department of Biomedical Sciences, but it currently lacks the components necessary to conduct live-cell imaging and can only capture static timepoints. The microscope software and equipment upgrade we are requesting would permit for time-lapse imaging of live cells over long periods of time. Live imaging allows for the observation of dynamic structure function events in cells, which will generate significantly more qualitative and quantitative data compared to current capabilities. Given that many labs in the department rely heavily on fluorescence microscopy, this equipment upgrade will be of benefit to multiple faculty and their trainees.