Toshi Kawate, PhD
Associate Professor
Department of Molecular Medicine
Toshi Kawate's LabCornell University College of Veterinary Medicine
C4-151 Veterinary Medical Center
Ithaca, NY 14853
Profile
Research/Clinical Interests
Extracellular signaling plays a central role in cell-cell communication for all multicellular organisms, orchestrating various life processes from body formation to brain function. This diverse and important signaling is exquisitely controlled by a variety of membrane-spanning proteins, including transporters and ion channels. Our research interest focuses on understanding how these dynamic and fine-tuned proteins are built, how they release/receive signals, and how they integrate and convey these signals across the cell membrane. In particular, we are interested in the ion channels that regulate extracellular ATP-mediated signaling, a newly emerging field in cell-cell communication throughout the human body.
Education
- Ph D, Cellular, Molecular, Biophysical Studies, Columbia University, 2005
- MS, Medical Science, Osaka University, 2000
- BS, Biology, Osaka University, 1998
Biography/Professional Experience
- 2009-2011, Postdoctoral Fellow, NINDS, Laboratory of Dr. Kenton Swartz, National Institutes of Health
- 2005-2009, Postdoctoral Fellow, The Vollum Institute, Laboratory of Dr. Eric Gouaux, Oregon Health and Science University
- 2001-2005, Graduate Student, Department of Biochemistry and Biophysics, Laboratory of Dr. Eric Gouaux, Columbia University
- 2000-2001, Research Assistant, Department of Internal Medicine, Laboratory of Dr. Thomas Sato. UT Southwestern Medical Center at Dallas
Awards and Honors
- 2015-2017, Young Investigators Grants, The Human Frontier Science Program,
- 2011-2014, NIH Pathway to Independence Award (R00)
- 2010, NIH Fellows Award for Research Excellence
- 2010, NIH Pathway to Independence Award (K99)
Professional/Academic Affiliations
2002, Biophysical Society
Publications
Selected Publications
- Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T. (2025) ATP-release pannexin channels are gated by lysophospholipids. eLife. DOI: 10.7554/eLife.107067.
- Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. (2024) The C-terminal activating domain promotes pannexin 1 channel opening. Proc Natl Acad Sci U S A. 2024 DOI: 10.1073/pnas.2411898121.
- Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T. (2020) The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition. eLife. DOI: 10.7554/eLife.54670. PMID: 32048993
- Michalski, K., Henze, E., Nguyen, P., Lynch, P., and Kawate, T. (2018) The weak voltage dependence of pannexin 1 channels can be tuned by N-terminal modifications. J Gen Physiol. DOI: 10.1085/jgp.201711804.
- Karasawa, A., Michalski, K., Mikhelzon, P., and Kawate, T. (2017) The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. eLife DOI: 10.7554/eLife.31186
- Karasawa A. and Kawate, T. (2016) Structural basis for subtype-specific inhibition of the P2X7 receptor. eLife. DOI: 10.7554/eLife.22153
