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Toshi Kawate, PhD

Associate Professor

Department of Molecular Medicine

Toshi Kawate's Lab

Cornell University College of Veterinary Medicine
C4-151 Veterinary Medical Center
Ithaca, NY 14853

Profile

Research/Clinical Interests

Extracellular signaling plays a central role in cell-cell communication for all multicellular organisms, orchestrating various life processes from body formation to brain function. This diverse and important signaling is exquisitely controlled by a variety of membrane-spanning proteins, including transporters and ion channels. Our research interest focuses on understanding how these dynamic and fine-tuned proteins are built, how they release/receive signals, and how they integrate and convey these signals across the cell membrane. In particular, we are interested in the ion channels that regulate extracellular ATP-mediated signaling, a newly emerging field in cell-cell communication throughout the human body.

Education

  • Ph D, Cellular, Molecular, Biophysical Studies, Columbia University, 2005
  • MS, Medical Science, Osaka University, 2000
  • BS, Biology, Osaka University, 1998

Biography/Professional Experience

  • 2009-2011, Postdoctoral Fellow, NINDS, Laboratory of Dr. Kenton Swartz, National Institutes of Health
  • 2005-2009, Postdoctoral Fellow, The Vollum Institute, Laboratory of Dr. Eric Gouaux, Oregon Health and Science University
  • 2001-2005, Graduate Student, Department of Biochemistry and Biophysics, Laboratory of Dr. Eric Gouaux, Columbia University
  • 2000-2001, Research Assistant, Department of Internal Medicine, Laboratory of Dr. Thomas Sato. UT Southwestern Medical Center at Dallas

Awards and Honors

  • 2015-2017, Young Investigators Grants, The Human Frontier Science Program,
  • 2011-2014, NIH Pathway to Independence Award (R00)
  • 2010, NIH Fellows Award for Research Excellence
  • 2010, NIH Pathway to Independence Award (K99)

Professional/Academic Affiliations

2002, Biophysical Society

Publications

Selected Publications

  1. Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T. (2025) ATP-release pannexin channels are gated by lysophospholipids. eLife. DOI: 10.7554/eLife.107067.
  2. Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. (2024) The C-terminal activating domain promotes pannexin 1 channel opening. Proc Natl Acad Sci U S A. 2024 DOI: 10.1073/pnas.2411898121.
  3. Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T. (2020) The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition. eLife. DOI: 10.7554/eLife.54670. PMID: 32048993
  4. Michalski, K., Henze, E., Nguyen, P., Lynch, P., and Kawate, T. (2018) The weak voltage dependence of pannexin 1 channels can be tuned by N-terminal modifications. J Gen Physiol. DOI: 10.1085/jgp.201711804.
  5. Karasawa, A., Michalski, K., Mikhelzon, P., and Kawate, T. (2017) The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. eLife DOI: 10.7554/eLife.31186
  6. Karasawa A. and Kawate, T. (2016) Structural basis for subtype-specific inhibition of the P2X7 receptor. eLife. DOI: 10.7554/eLife.22153