“Two-component regulatory systems and antimicrobial resistance in Klebsiella pneumoniae”

Biography:

Dr. Anne-Catrin Uhlemann is an Associate Professor of Medicine in the Division of Infectious Diseases at Columbia University Irving Medical Center, where she also directs the CUIMC Microbiome & Pathogen Collaborative Center and the Columbia University O’Brien Center for Benign Urology. She completed her medical training at the Eberhard-Karls-University in Tubingen, Germany and received her PhD from the University of London, UK. Dr. Uhlemann completed her residency in Internal Medicine and fellowship training in Infectious Diseases at Columbia University Irving Medical Center in New York. 

Dr. Uhlemann’s research focuses on the mechanisms and evolution of resistance to antibiotics, in particular in Gram-negative bacteria. This includes investigations into carbapenem-resistant Enterobacterales infections, which are considered an area of highest priority research by the CDC. Using combined large-scale genomic and genetic engineering approaches her group has characterized the emergence of resistance to novel treatment regimens, including the highly polygenetic nature of polymyxin resistance in Klebsiella pneumoniae and the impact of antimicrobial resistance on bacterial virulence and fitness.