The molecular mechanisms by which insulin secretion is stimulated, potentiated and inhibited in the pancreatic beta cell.

• D.Sc., Pharmacology, University of London, 1972
• PhD, Pharmacology, University of Nottingham, 1959

• 1998-Present, Professor of Pharmacology, Department of Molecular Medicine, Cornell University
• 1980-1998, Professor and Chairman, Department of Pharmacology, Cornell University
• 1996-1997, Visiting Professor, Department of Biomedical Science, University of Sheffield
• 1988-1989, Visiting Scientist, INSERM Unit 145
• 1982-1987, Director, Division of Biological Sciences, Cornell University
• 1986, Senior Research Scholar, Corpus Christi College
• 1978-1980, Professor and Chairman, Department of Physiology, Tufts University Medical School
• 1971-1978, Associate Professor, Department of Physiology, Harvard Medical School
• 1967-1978, Chief, Biochemical Pharmacology Unit of Massachusetts General Hospital
• 1973-1975, Visiting Scientist, Institute of Clinical Biochemistry, University of Geneva
• 1968-1974, Tutor, Department of Biochemistry, Harvard College
• 1968-1971, Assistant Professor, Department of Pharmacology, Harvard Medical School
• 1966-1968, Associate, Harvard Medical School Department of Pharmacology
• 1966-1968, Associate, Harvard Medical School Department of Pharmacology
• 1966-1968, Associate Professor, Harvard Medical School Department of Pharmacology
• 1962-1967, Research Associate in Medicine, Massachusetts General Hospital and Harvard Medical School
• 1961-1962, Empire Rheumatism Council Fellow, Middlesex Hospital Medical School
• 1960-1961, Pfeiffer Foundation Fellow, Middlesex Hospital Medical School
• 1957-1960, Lecturer, University of Nottingham

• Spégel, P., Sharoyko, V., Goehring, I., Danielsson, A., Malmgren, S., Nagorny, C., Andersson, L., Koeck, T., Sharp, G., Straub, S. (2013) Time-resolved metabolomics analysis of b-cells implicates the pentose phosphate pathway in the control of insulin release. 450:595-605.
• Straub, S., Sharp, G. (2012) Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins. 302:C1687-98.
• Zhao, Y., Fang, Q., Straub, S., Lindau, M., Sharp, G. (2010) Noradrenaline inhibits exocytosis via the G protein betagamma subunit and refilling of the readily releasable granule pool via the alpha(i1/2) subunit. 588:3485-3498.
• Zhao, Y., Fang, Q., Straub, S., Lindau, M., Sharp, G. (2010) Hormonal inhibition of endocytosis: novel roles for noradrenaline and G protein G(z). 588:3499-3509.
• Zhao, Y., Fang, Q., Straub, S., Sharp, G. (2008) Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel. 283:5306-16.

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• 2013, The Paul Lacy Medal 2014, The MidWest Islet Club
• 2001-2002, Research Awardee of the Alexander von Humboldt Foundation, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany