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Patrick L. McDonough

Faculty member

Department of Population Medicine and Diagnostic Sciences

Emeritus Associate Professor

Animal Health Diagnostic Center


Department of Population Medicine and Diagnostic Sciences
Cornell University College of Veterinary Medicine
Ithaca, NY 14853

Email: plm2@cornell.edu

Research Interest

My research interests are infectious diseases. Particularly, I'm interested in the microbiology of the Enterobacteriaceae and the microbial ecology of the intestinal tract; virulence mechanisms and pathogenesis of enteric bacterial infections, especially salmonellae, Helicobacter, Clostridium perfringens, Campylobacter and E. coli; immunity to Salmonella infections; Salmonella epidemiology and control programs; antimicrobial resistance in bacteria; development of new diagnostic assays and media for use in veterinary clinical microbiology; development of biosensors for the rapid detection of microorganisms; the use of fatty acid methyl ester analysis (FAME) in the identification of bacteria and fungi; the molecular epidemiology of microorganisms (using fingerprinting techniques such as FAME, PFGE, ribotyping).

Education

  • B.S. - 1973 Albright College, Reading, PA (major: Biology)
  • M.S. - 1976 Cornell University, Ithaca, NY (major: Bacteriology; minor Immunology)
  • Ph.D. - 1985 Cornell University, Ithaca, NY (major: Bacteriology; minors: Immunology, Epidemiology)

Biography/Professional Experience

  • 1973-1975 Graduate Research and Teaching Assistant, Department of Veterinary Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, NY
  • 1975-1979 Supervising Bacteriologist, Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY
  • 1979-1984 Graduate Research Asst. and PhD Candidate, Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY
  • 1984 Staff Microbiologist, Enteric Laboratory, Bureau of Laboratories, New York City Department of Health, New York, NY
  • 1984-1986 Principal Bacteriologist and Head of Bacteriology and Mycology Laboratory, Division of Animal Health, New Jersey Dept of Agriculture, Trenton,     NJ
  • 1986-1989 Instructor and Section Chief of Microbiology, Department of Pathology, Division of Diagnostic Laboratories, Tufts New England School of Veterinary Medicine, Tufts University, Boston, MA
  • 1989-1992 Senior Research Associate and Assistant Director-Bacteriology and Mycology Section, Diagnostic Center, College of Veterinary Medicine, Cornell University
  • 1992-2005 Assistant Professor and Assistant Director-Bacteriology and Mycology Section, Diagnostic Center, Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University
  • 2005-present Assistant Professor and Director-Bacteriology and Mycology Section, Diagnostic Center, Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University

Publications

  1. Wiedmann M, JL Bruce, R Knorr, M Bodis, E Cole, CI McDowell, PL McDonough, CA Batt. 1996. Ribotype diversity of Listeria monocytogenes strains associated with outbreaks of listeriosis in ruminants. J Clin Microbiol 34:1086-1090.
  2. McDonough PL, KW Simpson. 1996. Diagnosing emerging bacterial infections: salmonellosis, campylobacteriosis, clostridial toxicosis, and helicobacteriosis. In: RH Jacobson (ed) Laboratory Diagnosis of Infectious Disease: Interpretation of test results. Seminars in Veterinary Medicine and Surgery (Small Animal), 11:187-197.
  3. Barrow PA, M Desmidt, R Ducatelle, M Guittet, HMJF vander Heijden, PS Holt, JHJ Huis in't Velt, P McDonough, KV Nagaraja, RE Porter, K Proux, F Sisak, C Staak, G Steinbach, CJ Thorns, C Wray, F van Zijderveld. 1996. World Health Organization-supervised interlaboratory comparison of ELISAs for the serological detection of Salmonella enterica Serotype Enteritidis in chickens. Epidemiol Infect 117:69-77.
  4. Weidmann M, JL Bruce, C Keating, AE Johnsom, PL McDonough, CA Batt.1997. Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential. Infect Immun 65:2707-2716.
  5. Barwick RS, HO Mohammed, PL McDonough, ME White. 1997. Risk factors associated with the likelihood of Leptospira seropositivity in horses in the State of New York. Am J Vet Res 58:1097-1103.
  6. McDonough PL, RH Jacobson, JF Timoney, A Mutalib, DC Kradel, Y-F Chang, SJ Shin, DH Lein, S Trock, K Wheeler. 1998. Interpretations of Antibody Responses to Salmonella enterica Serotype Enteritidis gm-Flagellin in Poultry Flocks are Enhanced Using a Kinetics-ELISA (KELA). Clinical and Diagnostic Laboratory Immunology 5: 550-555.
  7. Barwick RS, HO Mohammed, PL McDonough, ME White. 1998. Equine leptospirosis and the potential hazards to human health. Prev Med 36:153-165.
  8. Cornetta AM, KW Simpson, D Strauss-Ayali, PL McDonough, RD Gleed. 1998. Use of a 13C-urea breath test for detection of gastric infection with Helicobacter spp. in dogs. Am J Vet Res 59: 1364-1369.
  9. Hoskins JD, J Williams, AF Roy, JC Peters, P McDonough. 1998. Isolation and characterization of Bordetella bronchiseptica from cats in southern Louisiana. Vet Immunol and Immunopathol 65:173-176.
  10. Simpson KW, PL McDonough, D Straus-Ayali, YF Chang, P Harpending, BA Valentine. 1999. Helicobacter felis infection in dogs: effect on gastric structure and function. Vet Pathol 36:237-248.
  11. Strauss-Ayali D, KW Simpson, AH Schein, PL McDonough, RH Jacobson, BA Valentine, J Peacock. 1999. Gastric Helicobacter spp. - Serological discrimination of infected and uninfected dogs. J Clin Microbiol 37:1280-1287.
  12. McDonough PL, D. Fogelman, S. J. Shin, M. A. Brunner, D. H. Lein. 1999. Salmonella enterica serotype Dublin infection: an emerging infectious disease for the Northeastern United States. J Clin Microbiol 37:2418-2427.
  13. Barwick RS, HO Mohammed, ER Atwill, PL McDonough, ME White. 1999. The prevalence of equine leptospirosis in New York State. Jap J Equine Science 9:119-124
  14. McDonough PL, SJ Shin, DH Lein. 1999. Diagnostic and public health dilemma of lactose- fermenting Salmonella enterica serotype Typhimurium in cattle in Northeastern United States. J Clin Microbiol 38:1221-1226.
  15. Simpson KW , D Strauss-Ayali, PL McDonough, Y-F Chang, and BA Valentine. 1999. Gastric function in dogs with naturally acquired Helicobacter spp infection. J of Vet Internal Med 13:507-515 (Editorial p. 505-506).
  16. McDonough PL, CA. Rossiter, RB. Rebhun, S M. Stehman, DH. Lein, SJ. Shin. 2000. Prevalence of Escherichia coli O157:H7 from cull dairy cows in New York State and comparison of culture methods used during preharvest food safety investigations. J Clin Microbiol 38: 318-322.
  17. Simpson KW, D Straus-Ayali, E Scanziani, RK Straubinger, PL McDonough, AF Straubinger, Y-F Chang, C Domeneghini, N Arebi, and J Calam. 2000. Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats. Infect Immun 68:779-790.
  18. Rurangirwa FR, CA Teitzel, J Cui, DM French, PL McDonough, and T. Besser. 2000. Streptococcus didelphis, sp. nov., a catalase positive streptococcus isolated from opossums Didelphis virginiana) with suppurative dermatitis and liver fibrosis. International J of Systematic and Evolutionary Microbiol 50:759-765
  19. Hassan L, HO Mohammed, PL McDonough, RN Gonzalez. 2000. A cross-sectional study on the prevalence of Listeria monocytogenes and Salmonella in the New York Dairy Herds. J Dairy Sci 83:2441-2447
  20. Spain CV, JM Scarlett, S Wade, and P McDonough. 2001. Prevalence of Enteric Zoonotic Agents in Cats Less Than One?year Old in Central New York State. J Vet Internal Med 15:33-38
  21. Hassan L, HO Mohammed, and PL McDonough. 2001. Management and milking practices associated with the presence of Listeria monocytogenes in dairy farms in New York State. Prev Vet Medicine 51:63-73
  22. Jeffers GT, JL Bruce, PL McDonough, J Scarlett, KJ Boor, and M Wiedmann. 2001. Comparative genetic characterization of Listeria monocytogenes isolates from human and animal listeriosis cases. Microbiol 147:1095-1104
  23. Simpson KW, D Strauss-Ayali, RK Straubinger R., E Scanziani, PL McDonough, AF Straubinger, M Esteves, JG Fox, Y-F Chang, C Domenghini, N Arebi, and J Calam. 2001. Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function. Helicobacter 6:1-14
  24. McDonough PL, CA Rossiter, Y-F Chang, SJ Shin, H Mohammed, S Stehman, J Dunlop, C Ramos, and DH Lein. Fatty acid characterization of Mycobacterium avium subsp. paratuberculosis - a useful tool assessing diversity of isolates. Appl Environ Microbiol Submitted
  25. Warnick LD, K Kanistanon, PL McDonough, L Power. Factors related to fecal shedding of Salmonella enterica subsp enterica group B in New York dairy farms with a history of clinical salmonellosis. Preventive Vet Med Submitted
  26. Raghavan PUM, SP McDonough, SC Barr, TJ Divers, P McDonough, Y-F Chang. Cloning and molecular characterization of an immunogenic 90-kDa membrane protein of Leptospira interrogans. Infect Immun Submitted
  27. Dheenadhayalan V, KS Shin, CF Chang, CD Chang, SP McDonough, PL McDonough, S Shin, DH Lein, Y-F Chang. Cloning and characterization of the genes coding for antigen 85A, 85B and 85C of Mycobacterium avium subsp. Paratuberculosis. FEMS Microbiol Letters Submitted
  28. Gerold A, E Scanziani, D Dailidiene, G Dalilide, J Adaska, PL McDonough, Y-F Chang, DE Berg, KW Simpson. Helicobacter pylori infection in cats: natural and experimental infection, strain characterization and eradication.

Awards and Honors

Phi Zeta, Alpha Chapter- Veterinary Honorary Society (1992)

Professional/Academic Affiliations

  • American Society for Microbiology (Section B:pathogenesis) (1977-present)
  • American Association of Veterinary Laboratory Diagnosticians (1979-present)
  • United States Animal Health Association (1982-present)
  • Society of Microbial Ecology and Disease (1990-present)
  • American Public Health Association (2001-present)
  • International Association for Paratuberculosis (1990-present)
  • Phi Zeta, Alpha Chapter (1992-present)
  • American Association of Veterinary Microbiologists (1980-1992)
  • Northeast Branch American Society for Microbiology (1988-89)
  • Northeast Association for Clinical Microbiology and Infectious Disease (1988-1990)

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