Periodontitis is a widespread inflammatory disease affecting a significant portion of the feline population, leading to progressive destruction of periodontal tissues, oral pain, tooth loss, and systemic complications. Current treatment strategies, including mechanical subgingival scaling and root planing under general anesthesia, combined with systemic antibiotic and anti-inflammatory therapies, present several limitations, such as incomplete disease resolution, poor patient compliance, and the risk of systemic side effects. Given these challenges, there is a critical need for a localized, minimally invasive, and sustained therapeutic approach to effectively manage feline periodontitis. In response to this unmet need, we propose the development of a biodegradable microneedle patch designed for localized and controlled drug delivery to periodontal tissues. This novel platform aims to enhance treatment efficacy by enabling direct delivery of antimicrobial and immunomodulatory agents at the site of infection and inflammation, while avoiding the systemic side effects associated with conventional treatments. The proposed study will focus on the fabrication, optimization, and preclinical validation of this microneedle-based drug delivery system. First, we will develop and optimize biodegradable microneedle patches using poly(lactic-co-glycolic acid) (PLGA), a biocompatible and FDA approved polymer known for its tunable degradation properties and ability to sustain drug release over extended periods. The feasibility and practical application of the microneedle patches will be tested in an ex vivo feline cadaver model to assess ease of handling, insertion precision, and tissue penetration. We will also assess the in vivo biocompatibility, tolerability, and safety of the microneedle patches in healthy feline models. This study aims to revolutionize the treatment of feline periodontitis by providing a targeted, minimally invasive, and highly effective therapeutic strategy. The successful completion of this research will not only advance feline periodontal health but also lay the groundwork for broader applications of microneedle-based drug delivery in veterinary and human dentistry. The translational potential of this approach extends beyond periodontitis treatment, offering a promising platform for localized immunotherapy and tissue regeneration in felines requiring precise and sustained therapeutic delivery.