Andrew Miller, DVM, DACVP

Andrew Miller, DVM, DACVP

Department of Biomedical Sciences

Associate Professor

Miller Lab


Department of Biomedical Sciences
Cornell University College of Veterinary Medicine
T5 006A Veterinary Research Tower, Box 18

Ithaca, NY 14853-6401

Office: 607-253-3559
Fax: 607-253-3541
Email: adm10@cornell.edu

Research Interest

My laboratory is focused primarily on studying the mechanisms underlying neurologic disease in animals utilizing both spontaneously arising disease and experimental models in a variety of laboratory animal species.  One current focus of my lab is in utilizing the dog as a model for human brain cancer, primarily meningeal and glial tumors. This is being done through a variety of histologic, immunohistochemical, and molecular studies in both the dog and cat. We are especially interested in determining the roles that novel gene mutations have in the genesis of canine and feline meningioma and are utilizing RNAseq to better understand the transcriptome of this tumor.  We are also actively involved in studying the immune cell microenvironment in canine brain tumors in order to determine if a relationship exists between immune cell infiltration and postsurgical outcome. Other active areas of research in my laboratory include analyzing the RNA transcriptome of canine soft tissue sarcomas, a common, but understudied tumor, in the dog. Due to my expertise in nonhuman primate pathology, I maintain numerous collaborations with researchers throughout the country aiding in various research studies.

Education

  • Residency, Veterinary Anatomic Pathology, Cornell University, 2008
  • DVM, Cornell University, 2005
  • BS in Animal Science, Cum Laude with Distinction in Research, Cornell University, 2001

Biography/Professional Experience

I am the Robert Hovey Udall Assistant Professor in the College of Veterinary Medicine.  I am a diplomate of the American College of Veterinary Pathologists (ACVP). I received my doctorate in veterinary medicine from Cornell University in 2005 and entered a residency in veterinary anatomic pathology at Cornell University, completed in 2008. I joined the faculty at the New England Primate Research Center, a division of Harvard Medical School as a research associate in 2008. I had achieved assistant professor by 2013 and held an appointment in the Pathology Department of the Massachusetts General Hospital during my tenure at the primate center. I joined the faculty in the Section of Anatomic Pathology as an Assistant Professor at Cornell University in fall of 2013. I have a strong interest in training veterinary students and pathology residents and preparing them for a career in comparative veterinary pathology. I believe that this is best done through hands on exposure to clinical cases and basic research techniques. I am involved nationally in the ACVP and other pathology groups including the Canine Brain Tumor Consortium, a multidisciplinary group organized through the National Cancer Institute. I strongly believe in the integration of teaching and collaborative research as a way to foster continued growth in the field of comparative veterinary pathology.  Veterinary students routinely rotate through my lab and I mentor a number of pathology residents on research projects during their residency.

Publications

  1. Mukai C, Choi E, Sams KL, Klampen EZ, Anguish L, Marks BA, Rice EJ, Wang Z, Choate LA, Chou S-P, Kato Y, Miller A, Danko CG, Coonrod SA. Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis. BMC Vet Res. 2020, in press
  2. Warren AL, Miller AD, de Lahunta A, Kortz G, Summers BA. Four cases of melanotic variant of malignant nerve sheath tumour: A rare, aggressive neoplasm in young dogs with a predilection for the spinal cord. J Comp Path. 2020, in press
  3. Andre NM, Miller AD, Whittaker G. Feline infectious peritonitis virus-associated rhinitis in a cat. JFMS Open Rep. 2020, in press
  4. Cavasin J, Miller AD, Duhamel GE. Intracerebral astrocytoma in a horse. J Comp Path. 2020, in press
  5. Baldanza VE, Rogic A, Yan W, Levine CB, Levine RA, Miller AD, McCleary-Wheeler AL. Evaluation of canonical Hedgehog signaling pathway inhibition in canine osteosarcoma. PLOS One 2020, epub April 29 2020
  6. Amin SB, Anderson KJ, Boudreau CE, Martinez-Ledesma E, Kocakavuk E, Johnson KC, Barthel FP, Varn FS, Kassab C, Ling X, Kim H, Barter M, Lau CC, Ngan CY, Chapman M, Koehler JW, Long JP, Miller AD, Miller CR, Porter BF, Rissi DR, Mazcko C, LeBlanc AK, Dickinson PJ, Packer RA, Taylor AR, Rossmeisl JH Jr, Woolard KD, Heimberger AB, Levine JM, Verhaak RGW. Comparative molecular life history of spontaneous canine and human gliomas.  Cancer cell. 2020, 37(2):243-257.
  7. Robinson JA, Guenthner G, Warfield R, Kublin JR, Smith MD, Shekarabi M, Miller AD, Burdo TH. Atrophy and death of non-peptidergic and peptidergic nociceptive neurons in SIV infection. Am J Pathol 2020, epub April 1.
  8. Delco ML, Goodale M, Talts JF, Pownder SL, Koff MF, Miller AD, Nixon B, Bonassar LJ, Lundgren-Åkerlund E, Fortier LA. Integrin α10β1-selected mesenchymal stem cells mitigate the progression of osteoarthritis in an equine talar impact model.  Am J Sports Med 2020, 48(3):612-623.
  9. Hales EN, Esparza C, Peng S, Dahlgren AR, Peterson JM, Miller AD, Finno CJ. Genome-wide association study and subsequent exclusion of ATCAY as a candidate gene involved in equine neuroaxonal dystrophy using two animal models.  Genes (Basel) 2020, 11(1):82.
  10. Fu DJ, Wang L, Chouairi FK, Rose IM, Abetov DA, Miller AD, Yamulla RJ, Schimenti JC, Flesken-Nikitin A, Nikitin AY. Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells.  Nat Commun 2020, 11(1):84.
  11. Demeter EA, Frank C, Porter B, Rissi D, Miller AD. Microtubule-associated protein 2 expression in canine glioma. Front Vet Sci. 2019, 6:395.
  12. Miller AD, Miller CR, Rossmeisl JR. Canine primary intracranial neoplasia: A clinicopathologic and comparative review of glioma, meningioma, and choroid plexus tumors. Front Onc. 2019, 9:1151. 
  13. Sariyer IK, Gordon J, Burdo TH, Wollebo HS, Gianti E, Donadoni M, Bellizzi A, Cicalese S, Loomis R, Robinson JA, Carnevale V, Steiner J, Ozdener MH, Miller AD, Amini S, Klein ML, Khalili K. Suppression of Zika virus infection in the brain by antiretroviral drug rilprivirine.  Mol Ther 2019, 27(12):2067-2079.
  14. Brown JL, Sones JL, Angulo CN, Abbott K, Miller AD, Boehm U, Roberson MS. Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse.  Sci Rep. 2019, 9(1):9641.
  15. Dalton MF, Stilwell JM, Krimer PM, Miller AD, Rissi D. Clinicopathologic features, diagnosis, and characterization of immune cell population in canine choroid plexus tumors. Front Vet Sci. 2019, 6:224.
  16. Andre N, Cossic B, Davies E, Miller AD, Whitaker G. Distinct mutation in the feline coronavirus spike protein cleavage-activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis. JFMS Open Rep. 2019, 5(1):2055116919856103
  17. Miller AD, Koehler JW, Donovan TA, Stewart JE, Porter BF, Rissi DR, Priestnall SL, Schulman FY. Canine ependymoma: Diagnostic criteria and common pitfalls. Vet Pathol. 2019, 56(6):860-867.
  18. Yan A, Joachims ML, Thompson LF, Miller AD, Canoll PD, Bynoe MS. CD73 promotes glioblastoma pathogenesis and enhances its chemoresistance via A2B adenosine receptor signaling. J Neurosci. 2019, 39(22):4387-4402.
  19. Parambeth JC, Ross CN, Miller AD, Austad SN, Lidbury JA, Suchodolski JS, Steiner JM. Serum cobalamin and folate concentrations in common marmosets (Callithrix jacchus) with chronic lymphocytic enteritis.  Comp Med, 2019 69(2):135-143.
  20. Kent M, Glass EN, Boozer L, Song RB, Hankin EJ, Barber RM, Platt SR, de Lahunta A, Miller AD. Correlation of MRI with the neuropathologic changes in two cats with bromethalin intoxication. J Am Anim Hosp Assoc. 2019, 55(3):e55302
  21. Miranda IC, Taylor KR, Castleman W, de Lahunta A, Summers BA, Miller AD. Schwannosis in three foals and a calf. Vet Pathol. 2019, 56(5):783-788.
  22. Garibay D, Zaborska KE, Shanahan M, Zheng Q, Kelly K, Montrose DC, Dannenberg AJ, Miller AD, Sethupathy P, Cumming BP.  TGR5 protects against colitis in mice, but vertical sleeve gastrectomy increases colitis severity. Obes Surg. 2019, epub Jan 8
  23. Newman AW, Miller A, Leal Yepes FA, Bitsko E, Nydam D, Mann S. The effect of the transition period and postpartum body weight loss on macrophage infiltrates in bovine subcutaneous adipose tissue. J Dairy Sci, 2019, 102(2):1693-1701
  24. Tse M, Shaw G, Miller AD. Microphthalmia with multiple anterior segments defects in Portuguese water dogs. Vet Pathol, 2019, 56(2):269-273.
  25. Zoll WM, Miller AD, Bandt C, Abbot JR. Primary leptomeningeal gliomatosis in a domestic shorthair cat. J Vet Diag Invest, 2019, 31(1):94-97. (pathology and data interpretation, writing/manuscript editing)
  26. Pecoraro HL, Felippe JB, Miller AD, Divers TJ, Simpson KW, Guyer KM, Duhamel GE.  Neuroborreliosis in a horse with common variable immunodeficiency. J Vet Diag Invest, 2019, 31(2):241-245. (pathology and data interpretation, writing/manuscript editing)

Dr. Miller’s complete bibliography can be accessed here: 

https://www.ncbi.nlm.nih.gov/myncbi/1ZymgvffhR0QW/bibliography/public/

Awards and Honors

C.L. Davis Foundation Samuel W. Thompson Lecture Award, 2018

Brittonkill Education Foundation Alumni Achievement Award, 2012

Professional/Academic Affiliations

  • American Society for Investigative Pathology
  • American College of Veterinary Pathologists
  • American Association of Veterinary Laboratory Diagnosticians
  • American Association of Neuropathologists