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Diego Diel, DVM, MS, PhD

Name goes here

Department of Population Medicine and Diagnostic Sciences

Associate Professor

Diel Research Lab


Department of Population Medicine and Diagnostic Sciences
Cornell University College of Veterinary Medicine
Ithaca, NY 14853

Office: 607.253.4359
Email: dgdiel@cornell.edu

Research Interest

My research interests are to understand the molecular mechanisms underlying virus-host interactions, focusing on the mechanisms underlying viral immune evasion that contribute to virus virulence and disease pathogenesis. My goal in studying virus-host interactions is to translate the basic knowledge generated with this research into improved vaccines and/or vaccine vectors for disease prevention and control. Other applied virology research interests include: (i) diagnostic assay development and (ii) livestock feed biosecurity.

Education

  • Ph.D, Virology, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. 2010.
  • MS, Virology, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. 2007.
  • DVM, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. 2004.

Biography/Professional Experience

  • 2019-Present   Associate Professor, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
  • 2016-2019       Section Leader, Virology, Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Environmental and Food Sciences, South Dakota State University, Brookings, SD.
  • 2014-2019       Assistant Professor, Department of Veterinary and Biomedical Sciences, College of Agriculture, Environmental and Food Sciences, South Dakota State University, Brookings, SD.
  • 2013-2014       Postdoctoral Research Associate, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign.
  • 2011-2013       Postdoctoral Research Microbiologist, Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, U.S. Department of Agriculture, Agricultural Research Services, Athens, GA.
  • 2011                Instructor, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign.
  • 2007-2010       Visiting Scholar/Research Assistant, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign.
  • 2005-2010       Graduate Research Assistant, Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil.
  • 2004-2005       Intern, Virology Sector, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Publications

  • Bauermann, F.V., Hause B., Buysse, A.R., Diel, D.G.  Identification and genetic characterization of porcine hepe-astrovirus (bastrovirus) in the United States. Accepted, Archives of Virology, May 15, 2019.
  • Fernandes, M.H.V., Maggioli, M.F., Otta, J., Joshi, L.R., Lawson, S., Diel, D.G. 2019. Senecavirus A 3C protease mediates host cell apoptosis late in infection. Frontiers in Immunology, 10:363. doi: 10.3389/fimmu.2019.00363.
  • Ramírez, M., Bauermann, F.V., Navarro, D., Rojas, M., Manchego, A., Nelson, E.A., Diel, D.G., Rivera, H. 2019. Detection of porcine reproductive and respiratory syndrome virus (PRRSV) 1-7-4-type strains in Peru. Transboundary and Emerging Diseases, 1-7. doi: 10.1111/tbed.13134.
  • Joshi, L.R., Bauermann, F.V., Hain, K.S., Kutish, G.F., Armién, A.G., Lehman, C.P., Regg Neiger, Afonso, C.L., Tripathy, D.N., Diel, D.G. 2019. Detection of fowlpox virus carrying distinct genome segments of reticuloendotheliosis virus. Virus Research, Oct 22. pii: S0168-1702(18)30556-2. doi: 10.1016/j.virusres.2018.10.017.
  • Fernandes, M.H.V., Maggioli, M.F., Joshi, L.R., Clement, T., Faccin, T.C., Rauh, R., Bauermann, F.V., Diel, D.G. 2018. Pathogenicity and cross-reactive immune responses of a historical and a contemporary Senecavirus A strains in pigs. Virology, Sep;522:147-157. doi: 10.1016/j.virol.2018.06.003.
  • Joshi, L.R., Okda, F.O., Singrey, A., Maggioli, M.F., Faccin, T.C., Fernandes, M.H.V., Hain, K.S., Dee, S., Bauermann, F.V., Nelson, E.A., Diel, D.G. 2018. Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant Orf virus vector expressing the spike protein. Archives of Virology, Sep;163(9):2327-2335. doi: 10.1007/s00705-018-3855-1.
  • Dee, S., Bauermann, F.V., Niederwerder, M., Singrey, A. Clement, T., de Lima, M., Long, C., Patterson, G., Sheehan, M., Stoian, A., Petrovan, V., Jones, C., de Jong, J., Ji, J., Spronk, G., Hennings, J., Zimmerman, J., Rowland, R.R., Nelson, E., Sundberg, P., Diel, D.G. 2018. Survival of viral pathogens in animal feed ingredients under transboundary shipping models. PLOS One, Mar 20;13(3):e0194509. doi: 10.1371/journal.pone.0194509. eCollection 2018.
  • Estima-Silva, P., Oliveira, P.A., Coelho, A.C.B., Echenique, J.V.Z., Marcolongo-Pereira, C., de Lima, M., Diel, D.G., Schild, A.L. Identification of equine herpesvirus type 1 as cause of abortion in mares in Southern Brazil. Accepted. Brazilian Journal of Veterinary and Animal Science. March 2018.
  • Maggioli, M.F., Lawson, S., de Lima, M., Joshi, L.R., Faccin, T.C., Bauermann, F.V., Diel, D.G. 2018. Adaptive immune responses following Senecavirus A infection in pigs. Journal of Virology, Jan 17; 92(3). pii: e01717-17. doi: 10.1128/JVI.01717-17.
  • Martins, M., Joshi, L.J., Rodrigues, F.S., Anziliero, D., Frandoloso, R., Kutish, G.F., Rock, D.L., Weiblen, R., Flores, E.F., Diel, D.G. 2017. Immunogenicity of ORFV-based vectors expressing the rabies virus glycoprotein in livestock species. Virology, Nov; 511:229-239. doi.org/10.1016/j.virol.2017.08.027.
  • Khatiwada, S., Delhon, G., Ponnuraj, P., Chaulagain, S., Luo, S., Diel, D.G., Flores, E.F., Rock, D.L. 2017. A novel poxviral virion protein inhibits NF-κB signaling early in infection. PLOS Pathogens, Aug 7; 13(8):e1006561. doi: 10.1371/journal.ppat.1006561.
  • Okda, F.A., Lawson, S., Singrey, A., Nelson, J., Hain, K.S., Joshi, L.R., Christopher-Hennings, J., Nelson, E.A., Diel, D.G.  2017. The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing epitopes. Virology, Jun 22; 509:185-194. doi:10.1016/j.virol.2017.06.013.
  • Bauermann, F.V., Joshi, L.R., Mohr, K.A., Kutish, G., Meier, P., Chase, C., Christopher-Hennings, J., Diel, D.G. 2017. A novel bovine papillomavirus type in the genus Dyokappapapillomavirus. Archives of Virology, Jun 14. doi: 10.1007/s00705-017-3443-9.
  • Van Noort, A., Nelsen, A., Pillatzki, A.E., Diel, D.G., Li, F., Nelson, E., Wang, X. 2017. Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2', 3'-cGAMP VacciGradeTM adjuvant exacerbates viremia after virus challenge. Virology Journal, Apr 12;14(1):76. doi: 10.1186/s12985-017-0746-0.
  • Joshi, L.R., Fernandes, M.H.V., Clement, T., Lawson, S., Pillatzki, A., Resende, T.P., Vanucci, F.A., Kutish, G.F., Nelson E.A., Diel, D.G. 2016. Pathogenesis of Senecavirus A infection in finishing pigs. Journal of General Virology. Oct 14 doi:10.1099/jgv.0.000631.
  • Hain, K.S., Joshi, L.R., Okda, F., Nelson J., Singrey, A., Lawson, S., Martins, M., Pillatzki, P., Kutish, G.F., Nelson, E.A., Flores, E.F., Diel, D.G. 2016. Immunogenicity of a Recombinant Parapoxvirus Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus. Journal of General Virology. Aug 24. doi: 10.1099/jgv.0.000586.
  • Cardenas-Garcia, S., Dunwoody, R. P., Marcano, V., Diel, D.G., Williams, R. J., Gogal Jr., R. M., Brown, C. C., Miller, P. J., Afonso, C. L. 2016. Effects of Chicken Interferon Gamma on Newcastle Disease Virus Vaccine Immunogenicity. PLOS One, Jul 13;11(7):e0159153. doi: 10.1371/journal.pone.0159153.
  • Diel, D.G., Lawson S., Okda F., Singrey, A., Clement T., Fernandes, M.H.V., Christopher-Hennings, J., Nelson, E.A. 2016. Porcine epidemic diarrhea virus: an overview of current virological and serological diagnostic methods. Virus Research, May 14. pii: S0168-1702(16)30209-X. doi: 10.1016/j.virusres.2016.05.013.
  • Burmakina, G., Malogolovkin, A., Tulman, E.R., Zsak, L., Delhon, G., Diel, D.G., Shobogorov, N.M., Morgunov, Y.P., Morgunov, S.Y., Kutish, G.F., Kolbasov, D., Rock, D.L. 2016. African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever. Journal of General Virology, April 25. doi: 10.1099/jgv.0.000490.
  • Joshi, L.R., Mohr, K.A., Clement, T., Hain, K.H., Myers, B., Yaros, Y., Nelson, E.A., Christopher-Hennings, J., Gava, D., Schaefer, R., Caron, L., Dee, S., Diel, D.G. 2016. Detection of the Emerging Picornavirus Senecavirus A in Pigs, Mice and Houseflies. Journal of Clinical Microbiology, June, 54(6):1536-45. doi: 10.1128/JCM.03390-15.
  • Clement, T., Singrey, A., Lawson, S., Okda, F., Nelson, J., Diel, D.G., Nelson, E.A., Christopher-Hennings, J. 2016. Measurement of neutralizing antibodies against porcine epidemic diarrhea virus in sow serum, colostrum, milk and piglet serum after feedback. Journal of Swine Health and Production, 24(3):147-153.
  • Susta, L., Diel, D.G., Courtney, S., Cardenas-Garcia, S., Sundick, R.S., Miller, P.J., Brown, C.C., Afonso, C.L. 2015. Expression of chicken interleukin-2 by a highly virulent strain of Newcastle disease virus leads to decreased systemic viral load but does not significantly affect mortality in chickens. Virology Journal, Aug 8; 12:122. doi: 10.1186/s12985-015-0353-x.
  • Huang, T., Tulman, E.R., Diel, D.G., Khatiwada, S., Sims, W., Edwards, J.F., Wen, X., Kutish, G.F., Rock, D.L., Delhon, G. 2015. Coinfection with multiple strains of bovine papular stomatitis virus. Archives of Virology, Jun, 16, 0(6):1527-32. doi: 10.1007/s00705-015-2394-2.
  • Malogolovkin, A., Burmakina, G., Tulman, E.R., Delhon, G., Diel, D.G., Salnikov, N., Kutish, G. F., Kolbasov, D., Rock, D. L. 2015. African swine fever virus CD2v and C-type lectin gene loci mediate serologic specificity. Journal of General Virology, April, 96(Pt 4):866-73. doi: 10.1099/jgv.0.000024.
  • Cardenas-Garcia, S., Diel, D.G., Susta, L., Yu, Q., Miller, P.J., Brown, C., Afonso, C.L. 2015. Development of an improved vaccine evaluation protocol to compare the efficacy of Newcastle disease vaccines. Biologicals, March, 43(2):136-45. doi:10.1016/j.biologicals. 2014.11.003.
  • Jia, J., Delhon, G., Tulman, E.R., Diel DG, Osorio, F.A., Wen, X., Kutish, G.F., Rock, D.L. 2014. Novel Gammaherpesvirus Functions Encoded by Bovine herpesvirus 6 (Bovine Lymphotropic virus). Journal of General Virology. May 16. pii: vir.0.066951-0. doi: 10.1099/vir.0.066951-0.

Awards and Honors

Certificate of Merit, U.S. Department of Agriculture, Agricultural Research Services, 2013.
•    Excellence in dedication and service and for outstanding mentoring and teaching of visiting scientists.

National Council for Scientific and Technological Development (CNPq/Brazil) Graduate
Fellowship, 2005-2007.

Professional/Academic Affiliations

  • 2017-Present   American Society for Virology (ASV).
  • 2016-Present   American Association of Veterinary Laboratory Diagnosticians (AAVLD).
  • 2014-Present   American Association of Veterinary Immunologists (AAVI).
  • 2014-Present   Conference of Research Workers on Animal Health (CRWAD).
  • 2012-Present   American Society for Microbiology (ASM).
  • 2004-Present   Regional Counsel of Veterinary Medicine (CRMV), Rio Grande do Sul, Brazil.
  • 2011-2012       American Association of Avian Pathologists (AAAP).

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