Gunther Hollopeter, PhD

Department of Molecular Medicine

Assistant Professor

Gunther Hollopeter's Lab

Department of Molecular Medicine
Cornell University College of Veterinary Medicine
Ithaca, NY 14853

Office: 607.253.3604


Research Interest

My laboratory elucidates mechanisms by which cellular machines regulate membrane trafficking. We employ a truly multidisciplinary approach that combines genetic screens and live imaging in the roundworm, Caenorhabditis elegans, with protein biochemistry and structural biology. We recently discovered that a conserved class of membrane-associated proteins initiate endocytosis by converting the AP2 clathrin adaptor complex to an active conformation. Currently, we are working out how another class of highly conserved proteins are acting as negative regulators of the endocytic machinery. Ongoing projects will identify additional mediators of endocytosis and determine their function at the molecular, cellular and organismal levels. Our long-term goal is to understand how the endocytic machinery influences the form and function of multicellular systems such as tissues and organs. We also aim to expand our repertoire of structural biology approaches via collaborations within the department.


  • PhD, Neuroscience, University of California, San Francisco, 2005
  • BS, Cell and Molecular Biology, University of Washington, Seattle, 1996

Biography/Professional Experience

  • 2015-Present, Assistant Professor, Cornell University
  • 2011-2015, Visiting Scholar, Stowers Institute
  • 2006-2015, Postdoctoral Research Fellow, University of Utah


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Awards and Honors

  • 2007-2010, Jane Coffin Childs Postdoctoral Fellowship, Jane Coffin Childs Memorial Fund for Medical Research
  • 2004-2005, Wheeler Center for the Neurobiology of Addiction Predoctoral Fellowship, UCSF
  • 2001-2004, American Heart Association Predoctoral Fellowship, American Heart Association