John Schimenti, PhD
Our lab investigates the genetics and mechanisms of reproduction, meiosis, and genome maintenance. A major focus concerns checkpoint mechanisms that detect errors in germ cell development so as to protect against chromosome aberrations and birth defects in offspring. We also study how defects in DNA replication lead to genetic aberrations, developmental abnormalities, and cancer. Finally, we have undertaken a project to identify human infertility alleles in human populations using CRISPR-mediated modeling in mice.
- BA, Rutgers University
- PhD, University of Cincinnati Childrens Hospital
- Post Doc, Princeton University
- 1987 - 1992 Assistant Professor, Department of Genetics, Case Western Reserve University
- 1992 - 2004 Staff Scientist, The Jackson Laboratory
- 2004 - 2019 Director, Cornell Center for Vertebrate Genomics
- 2004 - Present Professor of Genetics, Cornell University
Singh, P., Patel, R., Palmer, N., Grenier, J., Paduch, D., Kaldis, P., Grimson, A. and Schimenti, J. (2019) CDK2 kinase activity regulates male germ cell fate. Development 146: dev180273.
McNairn, A., Chuang, C., Bloom, J., Wallace, M. and Schimenti, J. (2019) Female-biased embryonic death from inflammation induced by genomic instability. Nature, 567: 105-108.
Rinaldi, V., Bolcun-Filas, E., Kogo, H., Kurahashi, H. and Schimenti, J. (2017) The DNA damage checkpoint eliminates mouse oocytes with chromosome synapsis failure. Molecular Cell 67:1026-1036.
Rinaldi, V., Hsieh, K., Munroe, R., Bolcun-Filas, E. and Schimenti, J. (2017) Pharmacological inhibition of the DNA damage checkpoint prevents radiation-induced oocyte death. Genetics 206: 1823-28.
- McNairn, A., Rinaldi, V. and Schimenti, J. (2017) Repair of meiotic DNA breaks and homolog pairing in mouse meiosis requires a minichromosome maintenance (MCM) paralog. Genetics 205:529-537. PMID: 27986806 DOI: 10.1534/genetics.116.196808
- Kartha, N., Shen, L., Maskin, C., Wallace, M. and Schimenti, J. (2016) The chromatin remodeling component Arid1a is a suppressor of spontaneous mammary tumors in mice. Genetics 203:1601-11.
- Bai, G., Smolka, M. and Schimenti, J. (2016) Chronic DNA replication stress induces senescence by TRP53-dependent downregulation of the Minichromosome Maintenance 2-7 factors. PLoS Genetics 12:e1005787.
- Singh, P. and Schimenti, J. (2015) The genetics of human infertility by functional interrogation of SNPs. PNAS, 112:10431-36. PMC4547237.
- Singh, P., Schimenti, J. and Bolcun-Filas, E. A mouse geneticist’s practical guide to CRISPR applications. (2015) Genetics. 199:1-15.
- Luo, Y., Hartford, S., Zheng, R., Southard, T., Shima, N., and Schimenti, J. Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. (2014) PLoS Genetics 10:e1004471.
- Bolcun-Filas, E., White, M., Rinaldi, V. and Schimenti, J. Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint. (2014) Science, 343:533-536.
- Wallace, M., Southard, T. Schimenti, K. and Schimenti, J. (2014) Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene 33:3688-95.
Awards and Honors
- March of Dimes Basil O'Connor Starter Scholar Research Award
- Searle Scholars Award
- Presidential Young Investigator Award, National Science Foundation
- Fellow, American Association for the Advancement of Science
- James Law Professor of Genetics, Cornell College of Veterinary Medicine
- SUNY Chancellor's Award for Excellence in Scholarship and Creative Activities
(Primary) Department of Biomedical Sciences, College of Veterinary Medicine
(Joint) Department of Molecular Biology and Genetics