Lymphoma is one of the most common cancers in dogs with few treatment options available. Traditional injectable chemotherapeutic drugs have been used to extend quality of life, achieve clinical remissions, and slow cancer progression, but are not feasible options for many families. Additional safe, low cost therapies are needed for canine patients. 

Multi-agent chemotherapy plus prednisone (an oral steroid pill) is the standard treatment. However, this is not a viable option for many families with affected dogs. The goal of this study is to compare outcomes, safety, and quality of life in dogs with large cell lymphoma receiving either prednisone plus a supplement, prednisone plus a specific antibiotic that may have anti-cancer activity, or prednisone plus a conditionally approved oral anti-cancer drug.

Eligibility: Dogs seen by the Cornell University Hospital for Animals who have been diagnosed with large cell lymphoma who are not already on oral prednisone.

Compensation: This study is sponsored by the Cornell Richard P. Riney Canine Health Center. All testing related to this study is covered by the sponsor. This includes the costs of medications, diagnostic testing, and evaluation pertinent to the study. Any tests or procedures unrelated to the study are your responsibility.

Owner Responsibilities: This is a 12 week study. You are responsible for administering study medications as directed and must return your dog to CUHA for follow-up appointments according to a specific timeline. There is a possibility (depending upon which arm of the study your dog is randomized to) that we may take a small amount of extra blood and lymph node aspirates at time points where these procedures are already occurring (so your dog will not have an extra needle poke). You will be asked to complete an extra questionnaire about your dog's health at study-related visits. All study procedures, time requirements, and responsibilities will be provided to you in a project outline.

Principal Investigator: Kelly Hume, DVM, DACVIM

Contact/Schedule an Appointment: If you have a dog you think may be eligible please call the clinical trials coordinator at 607.253.3060, or email vet-research@cornell.edu