Julia Felippe’s academic appointment includes large animal clinical care and DVM-student/resident training in internal medicine at the Cornell University Hospital for Animals; teaching in the DVM, graduate and undergraduate curricula; and a research program in the field of immunology. The major thrust of her research and training has been developmental immunology and immunodeficiencies. Her laboratory studies immune competence in the equine neonate and response to vaccinations; and common variable immunodeficiency (CVID) in horses, a fatal, non-familial, late-onset condition that leads to impaired antibody production and recurrent infections. Her research group demonstrated that the antibody-producing cells (known as B cells) become absent in the bone marrow, blood and peripheral tissues of affected horses, following an epigenetically regulated decrease in the expression of B cell lineage transcription factor genes. Her current research efforts pursue the modification of the epigenetic aberrations in hematopoietic stem cells and lineage precursors in vitro for autologous transplantation to patients.