This page summarizes the publications generated by the Simpson Lab

Inflammatory bowel disease

Mansfield, C.S., James, F.E., Craven, M., Davies, D.R., O'Hara, A.J., Nicholls, P.K., Dogan, B., MacDonoug, S.P., Simpson, K.W. Remission of histiocytic ulcerative colitis in Boxer dogs correlates with eradication of invasive intramucosal E. Coli. J. Vet. Intern. Med. 23, 964-969.

Baumgart, M., Dogan, B., Rishniw, M., Weitzman, G., Bosworth, B., Yantiss, R., Orsi, R.H., Wiedmann, M., McDonough, P., Kim, S.G., Berg, D., Schukken, Y., Scherl, E., Simpson, K.W., 2007. Culture Independent Analysis of Ileal Mucosa Reveals a Selective Increase in Invasive Escherichia Coli of Novel Phylogeny Relative to Depletion of Clostridiales in Crohn's Disease Involving the Ileum. ISME J. 1, 403-418.

Simpson, K.W., Dogan, B., Rishniw, M., Goldstein, R.E., Klaessig, S., McDonough, P.L., German, A.J., Yates, R.M., Russell, D.G., Johnson, S.E., Berg, D.E., Harel, J., Bruant, G., McDonough, S.P., Schukken, Y.H., 2006. Adherent and Invasive Escherichia Coli is Associated with Granulomatous Colitis in Boxer Dogs. Infect. Immun. 74, 4778-4792. 

Janeczko, S., Atwater, D., Bogel, E., Greiter-Wilke, A., Gerold, A., Baumgart, M., Bender, H., McDonough, P.L., McDonough, S.P., Goldstein, R.E., Simpson, K.W., 2008. The Relationship of Mucosal Bacteria to Duodenal Histopathology, Cytokine mRNA, and Clinical Disease Activity in Cats with Inflammatory Bowel Disease. Vet. Microbiol. 128, 178-193. 

Smith, A.A., Posner, L.P., Goldstein, R.E., Ludders, J.W., Erb, H.N., Simpson, K.W., Gleed, R.D., 2004. Evaluation of the Effects of Premedication on Gastroduodenoscopy in Cats. J. Am. Vet. Med. Assoc. 225, 540-544. 

Simpson, K.W., Fyfe, J., Cornetta, A., Sachs, A., Strauss-Ayali, D., Lamb, S.V., Reimers, T.J., 2001. Subnormal Concentrations of Serum Cobalamin (Vitamin B12) in Cats with Gastrointestinal Disease. J. Vet. Intern. Med. 15, 26-32. 


Jergens, A.E., Pressel, M., Crandell, J., Morrison, J.A., Sorden, S.D., Haynes, J., Craven, M., Baumgart, M., Simpson, K.W., 2009. Fluorescence in Situ Hybridization Confirms Clearance of Visible Helicobacter Spp. Associated with Gastritis in Dogs and Cats. J. Vet. Intern. Med. 23, 16-23. 

Recordati, C., Gualdi, V., Tosi, S., Facchini, R.V., Pengo, G., Luini, M., Simpson, K.W., Scanziani, E., 2007. Detection of Helicobacter Spp. DNA in the Oral Cavity of Dogs. Vet. Microbiol. 119, 346-351. 

Greiter-Wilke, A., Scanziani, E., Soldati, S., McDonough, S.P., McDonough, P.L., Center, S.A., Rishniw, M., Simpson, K.W., 2006. Association of Helicobacter with Cholangiohepatitis in Cats. J. Vet. Intern. Med. 20, 822-827. 

Priestnall, S.L., Wiinberg, B., Spohr, A., Neuhaus, B., Kuffer, M., Wiedmann, M., Simpson, K.W., 2004. Evaluation of "Helicobacter Heilmannii" Subtypes in the Gastric Mucosas of Cats and Dogs. J. Clin. Microbiol. 42, 2144-2151.

Straubinger, R.K., Greiter, A., McDonough, S.P., Gerold, A., Scanziani, E., Soldati, S., Dailidiene, D., Dailide, G., Berg, D.E., Simpson, K.W., 2003. Quantitative Evaluation of Inflammatory and Immune Responses in the Early Stages of Chronic Helicobacter Pylori Infection. Infect. Immun. 71, 2693-2703.

Simpson, K.W., Strauss-Ayali, D., Straubinger, R.K., Scanziani, E., McDonough, P.L., Straubinger, A.F., Chang, Y.F., Esteves, M.I., Fox, J.G., Domeneghini, C., Arebi, N., Calam, J., 2001. Helicobacter Pylori Infection in the Cat: Evaluation of Gastric Colonization, Inflammation and Function. Helicobacter 6, 1-14. 

Strauss-Ayali, D., Scanziani, E., Deng, D., Simpson, K.W., 2001. Helicobacter Spp. Infection in Cats: Evaluation of the Humoral Immune Response and Prevalence of Gastric Helicobacter Spp. Vet. Microbiol. 79, 253-265.

Neiger, R., Simpson, K.W., 2000. Helicobacter Infection in Dogs and Cats: Facts and Fiction. J. Vet. Intern. Med. 14, 125-133.

Simpson, K.W., Strauss-Ayali, D., Scanziani, E., Straubinger, R.K., McDonough, P.L., Straubinger, A.F., Chang, Y.F., Domeneghini, C., Arebi, N., Calam, J., 2000. Helicobacter Felis Infection is Associated with Lymphoid Follicular Hyperplasia and Mild Gastritis but Normal Gastric Secretory Function in Cats. Infect. Immun. 68, 779-790.

Simpson, K.W., McDonough, P.L., Strauss-Ayali, D., Chang, Y.F., Harpending, P., Valentine, B.A., 1999. Helicobacter Felis Infection in Dogs: Effect on Gastric Structure and Function. Vet. Pathol. 36, 237-248.

Simpson, K.W., Strauss-Ayali, D., McDonough, P.L., Chang, Y.F., Valentine, B.A., 1999. Gastric Function in Dogs with Naturally Acquired Gastric Helicobacter Spp. Infection. J. Vet. Intern. Med. 13, 507-515.

Cornetta, A.M., Simpson, K.W., Strauss-Ayali, D., McDonough, P.L., Gleed, R.D., 1998. Use of a [13C]Urea Breath Test for Detection of Gastric Infection with Helicobacter Spp in Dogs. Am. J. Vet. Res. 59, 1364-1369

Strauss-Ayali, D., Simpson, K.W., 1999. Gastric Helicobacter Infection in Dogs. Vet. Clin. North Am. Small Anim. Pract. 29, 397-414.

Strauss-Ayali, D., Simpson, K.W., Schein, A.H., McDonough, P.L., Jacobson, R.H., Valentine, B.A., Peacock, J., 1999. Serological Discrimination of Dogs Infected with Gastric Helicobacter Spp. and Uninfected Dogs. J. Clin. Microbiol. 37, 1280-1287.


Sekis, I., Ramstead, K., Rishniw, M., Schwark, W.S., McDonough, S.P., Goldstein, R.E., Papich, M., Simpson, K.W., 2009. Single-Dose Pharmacokinetics and Genotoxicity of Metronidazole in Cats. J. Feline Med. Surg. 11, 60-68.

Kiselow, M.A., Rassnick, K.M., McDonough, S.P., Goldstein, R.E., Simpson, K.W., Weinkle, T.K., Erb, H.N., 2008. Outcome of Cats with Low-Grade Lymphocytic Lymphoma: 41 Cases (1995-2005). J. Am. Vet. Med. Assoc. 232, 405-410.

Recordati, C., Radaelli, E., Simpson, K.W., Scanziani, E., 2008. A Simple Method for the Production of Bacterial Controls for Immunohistochemistry and Fluorescent in Situ Hybridization. J. Mol. Histol. 39, 459-462.

Dogan, B., Klaessig, S., Rishniw, M., Almeida, R.A., Oliver, S.P., Simpson, K., Schukken, Y.H., 2006. Adherent and Invasive Escherichia Coli are Associated with Persistent Bovine Mastitis. Vet. Microbiol. 116, 270-282.

McDonough, P.L., Simpson, K.W., 1996. Diagnosing Emerging Bacterial Infections: Salmonellosis, Campylobacteriosis, Clostridial Toxicosis, and Helicobacteriosis. Semin. Vet. Med. Surg. (Small Anim) 11, 187-197.

Simpson, K.W., 2001. The Emergence of Feline Pancreatitis. J. Vet. Intern. Med. 15, 327-328.

Simpson, K.W., Rishniw, M., Bellosa, M., Liotta, J., Lucio, A., Baumgart, M., Czarnecki-Maulden, G., Benyacoub, J., Bowman, D., 2009. Influence of Enterococcus Faecium SF68 Probiotic on Giardiasis in Dogs. J. Vet. Intern. Med.