The Clinical Pathology Laboratory is in the Department of Population Medicine and Diagnostic Sciences, and is also a unit of the Animal Health Diagnostic Center at Cornell University. The Laboratory is staffed by four clinical pathologists, all of whom are board-certified by the American College of Veterinary Pathologists, a laboratory manager, multiple medical technologists and veterinary technicians, and three administrative assistants. We also have three training positions including two clinical pathology residents and one intern. We have a high-volume, high-quality laboratory equipped with state-of-the-art analyzers. We provide diagnostic testing and professional consultation services to the Cornell University Hospital for Animals, to researchers affiliated with Cornell University and to private veterinary practitioners and researchers throughout New York, the USA, and worldwide.
The clinical pathology section is an academic unit with three mandates:
- Professional diagnostic service: We are committed to performing high-quality, timely, comprehensive, and accurate laboratory testing of animal specimens in the areas of hematology, clinical chemistry, diagnostic cytology, immunology, and urinalysis. As part of this service, we provide professional consultation for our laboratory results.
- Education: We are dedicated to educating current and future veterinarians in clinical pathology through our residency program, interactive case-based lectures, laboratories and seminars, elective laboratory rotations for students, interns and residents, and web-based educational resources (see eClinPath).
Research: We are committed to contributing to the advancement of knowledge in clinical pathology through investigative research. Our faculty and residents are actively involved in clinical applied research, which is a vital component of our residency training program. Current research areas of interest are:
- Hematopoietic neoplasia, such as leukemia and lymphoma
- Thrombotic disorders in animals
- Hematologic disorders, including iron deficiency anemia and immune-mediated hemolytic anemia
Clinical Pathology performs testing for a variety of researchers and contract laboratories. We can create customized panels, consisting of specific tests for research projects. We also provide consultation on study design (if desired), how to submit samples (with examples of request forms), and guidance on optimal sample collection, labeling, and shipping.
For all research projects, the project leader (or designated representative) must contact our laboratory manager before any samples can be accepted for analysis. We will require the following information when setting up a research account:
Hematologic disorders, such as immune-mediated hemolytic anemia
Hematopoietic neoplasia, such as leukemia and lymphoma
Thrombotic disorders in animals
The laboratory manager will use this information to formulate a plan so your research project will be performed in the most efficient manner possible.
For publications from the clinical pathology crew from the past 2 years, please see below.
"Candida albicans cholecystitis with associated hepatitis in a cat." Palermo SM, Newman AW, Koch MW. JFMS Open Rep. 2019 Jun 12;5(1):2055116919854165. doi: 10.1177/2055116919854165. eCollection 2019 Jan-Jun.
"The effect of the transition period and postpartum body weight loss on macrophage infiltrates in bovine subcutaneous adipose tissue." Newman AW, Miller A, Leal Yepes FA, Bitsko E, Nydam D, Mann S. J Dairy Sci. 2019 Feb;102(2):1693-1701. doi: 10.3168/jds.2018-15362. Epub 2018 Nov 22.
"Clinical Pathology of Donkeys and Mules." Goodrich EL, Behling-Kelly E. Vet Clin North Am Equine Pract. 2019 Dec;35(3):433-455. doi: 10.1016/j.cveq.2019.08.002. Review.
"Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge." Moore ES, Daugherity EK, Karambizi DI, Cummings BP, Behling-Kelly E, Schaefer DMW, Southard TL, McFadden JW, Weiss RS. J Biol Chem. 2019 Oct 25;294(43):15623-15637. doi: 10.1074/jbc.RA118.005729. Epub 2019 Aug 21.
"SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis." Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW. Nature. 2019 May;569(7757):565-569. doi: 10.1038/s41586-019-1140-4. Epub 2019 Apr 24.
"What is your diagnosis? Swab of an eyelid swelling from a tomato frog." Stokol T, Fefer G, Lejeune M, Steeil J, Neiffer D. Vet Clin Pathol. 2019 Sep;48(3):490-492. doi: 10.1111/vcp.12737. Epub 2019 Apr 23. No abstract available.
"Evaluation of automated erythrocyte methodology in new world camelids using the ADVIA 2120 hematology analyzer." Viesselmann LC, Flatland B, Stokol T, Sisson S, Schaefer DMW. Vet Clin Pathol. 2019 Jun;48(2):239-249. doi: 10.1111/vcp.12733. Epub 2019 Jun 9.
"Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse." Long AE, Javsicas LH, Stokol T, Felippe MJB, Frimberger AE. J Am Vet Med Assoc. 2019 Sep 15;255(6):716-721. doi: 10.2460/javma.255.6.716.
"Common bile duct obstruction palliated with common bile duct re-implantation (choledochoduodenostomy) in a cat." Hayes G, Devereux S, Loftus JP, Jager M, Duhamel G, Stokol T. Can Vet J. 2019 Oct;60(10):1089-1093.
"Immunohistochemical Labeling of Low-Density Lipoprotein Receptor and Scavenger Receptor Class B Type 1 Are Increased in Canine Lymphoma." Ceres K, Fitzgerald H, Quiznon KS, McDonough S, Behling-Kelly E. Frontiers in Veterinary Science. 2018;5:340. doi: 10.3389/fvets.2018.00340. Epub 2019 Jan 11.
"Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration." Serpa PBS, Brooks MB, Divers T, Ness S, Birschmann I, Papich MG, Stokol T. Frontiers in Veterinary Science. 2018 Dec;5:304. doi: 10.3389/fvets.2018.00304. Epub 2018 Dec 4.
"Pharmacokinetics of Human Recombinant C1-Esterase Inhibitor and Development of Anti-Drug Antibodies in Healthy Dogs." Wong C, Muguiro DH, Lavergne S, Behling-Kelly E, Goggs R. Vet Immunol Immunopathol. 2018 Sep;203:66-72. doi: 10.1016/j.vetimm.2018.08.006. Epub 2018 Aug 23.
"A Commercial Soy-Based Phospholipid Emulsion Accelerates Clot Formation in Normal Canine Whole Blood and Induces Hemolysis in Whole Blood from Normal and Dogs with Inflammatory Leukograms." Behling-Kelly EL, Wakshlag J. J Vet Emerg Crit Care (San Antonio). 2018 May;28(3):252-260. doi: 10.1111/vec.12716. Epub 2018 Apr 6.
"Influence of Multiple Reuse and Resterilization Cycles on the Performance of a Bipolar Vessel Sealing Device (LigaSure) Intended for Single Use." Kuvaldina A, Hayes G, Sumner J, Behling-Kelly E. Vet Surg. 2018 Sep 4. doi: 10.1111/vsu.12948. [Epub ahead of print]
"What is Your Diagnosis? Mandibular Mass In a Cat.: Newman AW, Asakawa MG, Stokol T. Vet Clin Pathol. 2018 Sep;47(3):501-502. doi: 10.1111/vcp.12617. Epub 2018 May 14. No abstract available.
"Subcutaneous Administration of Low-Molecular-Weight Heparin to Horses Inhibits Ex Vivo Equine Herpesvirus Type 1-Induced Platelet Activation." Stokol T, Serpa PBS, Brooks MB, Divers T, Ness S. Front Vet Sci. 2018 May 28;5:106. doi: 10.3389/fvets.2018.00106. eCollection 2018.
"Dogs with Acute Myeloid Leukemia or Lymphoid Neoplasms (large cell lymphoma or acute lymphoblastic leukemia) May Have Indistinguishable Mediastinal Masses on Radiographs." Epperly E, Hume KR, Moirano S, Stokol T, Intile J, Erb HN, Scrivani PV. Vet Radiol Ultrasound. 2018 Sep;59(5):507-515. doi: 10.1111/vru.12622. Epub 2018 May 3.
"A Retrospective Review of Acute Myeloid Leukaemia in 35 Dogs Diagnosed by a Combination of Morphologic Findings, Flow Cytometric Immunophenotyping and Cytochemical Staining Results (2007-2015)." Davis LL, Hume KR, Stokol T. Vet Comp Oncol. 2018 Jun;16(2):268-275. doi: 10.1111/vco.12377. Epub 2017 Dec 14.
"Diagnostic performance of cytology for assessment of hepatic lipid content in dairy cattle."
Fry MM, Yao B, Ríos C, Wong C, Mann S, McArt JAA, Nydam DV, Leal Yepes FA, Viesselmann L, Geick A, Goldin K, Jordan A, Behling-Kelly E. J Dairy Sci. 2018 Feb;101(2):1379-1387. doi: 10.3168/jds.2017-12897. Epub 2017 Dec 14.